5-Amino-1MQ vs AOD-9604.
Quick Verdict
5-Amino-1MQ is a nnmt inhibitor primarily researched for fat loss, nad+ preservation, metabolic optimization, muscle protection, while AOD-9604 is a gh fragment studied for fat loss without gh side effects. AOD-9604 has substantially more indexed research (18 studies) compared to 5-Amino-1MQ (2 studies).
Side-by-Side Analysis
| Dimension | 5-Amino-1MQ | AOD-9604 |
|---|---|---|
| Category | NNMT Inhibitor | GH Fragment |
| Mechanism | Selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that consumes SAM and depletes NAD+ pools while promoting fat storage. | Mimics GH fat-burning domain. |
| Half-Life | ~2 hours | ~1 hours |
| Route | Oral | SubQ |
| Typical Dose | 50000–100000 mcg | 300–300 mcg |
| Frequency | Daily | 7x/wk |
| Evidence Level | Preclinical | Preclinical |
| Indexed Studies | 2+ indexed | 18+ indexed |
| FDA Status | Research Only | Research Only |
| Lowest Price | $74.97 / 10mg via Bio Longevity Labs | $49.99 / 5mg via Amino Club |
| Per-mg Cost | $7.50/mg | $10.00/mg |
Mechanism of Action Comparison
How 5-Amino-1MQ Works
5-Amino-1MQ 5-Amino-1MQ is a small-molecule NNMT inhibitor studied in rodent models for its ability to reduce fat mass and raise NAD+ levels without dieting.
Selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that consumes SAM and depletes NAD+ pools while promoting fat storage. By blocking NNMT, 5-Amino-1MQ raises intracellular NAD+ levels, activates SIRT1, and shifts adipocytes toward lipolysis. Shown in rodent models to reduce fat mass without caloric restriction.
How AOD-9604 Works
AOD-9604 AOD-9604 is a synthetic fragment of human growth hormone studied for its ability to burn fat without the blood sugar or growth side effects of full GH.
Mimics GH fat-burning domain. Stimulates lipolysis and inhibits lipogenesis by acting on beta-3 adrenergic receptors in fat tissue, without binding to the GH receptor.
Key Mechanistic Difference
5-Amino-1MQ operates as a nnmt inhibitor, while AOD-9604 functions as a gh fragment — these are fundamentally different pharmacological approaches.
Research Evidence
5-Amino-1MQ
2 studies- NNMT inhibition induces browning of white adipose tissue and reduces fat massNeelakantan et al. demonstrate that selective NNMT inhibitor treatment in obese mice significantly reduces fat mass, inc…Preclinical
- NNMT inhibition protects against diet-induced obesityKraus et al. (Nature Communications): NNMT inhibition in mice prevents diet-induced obesity and improves insulin sensiti…Preclinical
AOD-9604
18 studies- AOD-9604 lipolysis stimulation in preclinical modelsNg et al. demonstrate AOD-9604 stimulates lipolysis and inhibits lipogenesis in adipose tissue without affecting IGF-1 o…Preclinical
- AOD-9604 clinical safety six randomized controlled trialsHeffernan et al.: Pooled analysis of 6 RCTs showing AOD-9604 is well-tolerated with a safety profile similar to placebo …Moderate
- AOD-9604 Phase IIb trial short-term fat reduction12-week Phase IIb trial: 1mg/day AOD-9604 produced 2.6 kg weight loss vs 0.8 kg placebo, with reductions in abdominal fa…Moderate
Vendor Pricing
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Frequently Asked Questions
Can I take 5-Amino-1MQ and AOD-9604 together?▼
Yes — 5-Amino-1MQ and AOD-9604 are identified as synergistic in interaction databases. They operate through complementary mechanisms and are commonly combined in research protocols.
Which has more research evidence — 5-Amino-1MQ or AOD-9604?▼
5-Amino-1MQ has 2 indexed studies (highest evidence: Preclinical). AOD-9604 has 18 indexed studies (highest evidence: Preclinical). AOD-9604 has a more extensive research base.
What is the price difference between 5-Amino-1MQ and AOD-9604?▼
At current verified vendor prices, 5-Amino-1MQ starts at $7.50/mg while AOD-9604 starts at $10.00/mg. Prices vary by vendor and vial size — see the full vendor comparison below.
Which is better for fat loss — 5-Amino-1MQ or AOD-9604?▼
Both are researched for fat loss. 5-Amino-1MQ addresses this via fat loss, nad+ preservation, metabolic optimization, muscle protection. AOD-9604 approaches it through fat loss without gh side effects. The optimal choice depends on your specific research protocol and which mechanism aligns with your objectives.
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Research Use Only — Not Medical Advice
This comparison is provided for educational and research purposes only. It does not constitute medical, prescribing, or treatment advice. Clinical data cited here is sourced from published peer-reviewed trials and FDA labels. Consult a qualified healthcare professional before making any decisions about medications or research compounds. PeptiDex is an informational resource and does not sell pharmaceutical products.