Community Stacks

Curated peptide protocols for specific goals. Build off the knowledge of the community.

Body Recomposition Stack

Maximize fat loss while preserving or building lean muscle the gold standard for total body transformation

Stack Compounds

RetatrutideLead compound triple GLP-1/GIP/glucagon agonism delivers ~24% weight loss while preserving muscle via glucagon-driven fat oxidation
TirzepatideFDA-approved dual agonist alternative 21% weight loss with superior glycemic control; the proven clinical backbone
CJC-1295Stimulates pulsatile GH release to maintain lean mass during aggressive caloric deficits
IpamorelinSelective GH amplifier pairs with CJC-1295 for synergistic muscle-sparing effects without cortisol spikes
TesamorelinFDA-approved for visceral fat specifically clinically proven 18% trunk fat reduction

Why It Works

GLP-1 agonists drive powerful fat loss through appetite suppression and metabolic remodeling, while GH peptides preserve and build muscle. Retatrutide's triple agonism provides the strongest fat-loss signal; CJC-1295 + Ipamorelin maintain anabolic drive. Tesamorelin specifically targets stubborn visceral fat. Together, they attack body composition from both sides maximizing fat loss while minimizing muscle catabolism.

Key Studies

  • Retatrutide Phase 2: ~24% weight loss at 48 weeks highest reported in any trial PubMed
  • Tirzepatide SURMOUNT Phase 3: up to 21% weight loss PubMed
  • CJC-1295 sustained GH/IGF-1 elevations in healthy adults PubMed

Fat Loss Focus Stack

Maximum fat loss through multi-pathway metabolic optimization

Stack Compounds

RetatrutideTriple agonist for superior appetite suppression and fat oxidation the most potent fat-loss peptide in trials
SemaglutideFDA-approved GLP-1 agonist with proven long-term weight loss and cardiovascular benefits
AOD-9604Directly stimulates lipolysis via GH fat-burning domain without affecting blood glucose or growth
MOTS-cActivates AMPK for enhanced fatty acid oxidation and cellular energy metabolism

Why It Works

Multi-pathway metabolism boost: GLP-1 agonists suppress appetite centrally, AOD-9604 attacks fat directly at the adipose tissue level, and MOTS-c improves the underlying metabolic machinery. Strong GLP-1 trial results combined with complementary fat-loss mechanisms.

Key Studies

  • Retatrutide Phase 2: ~24% weight loss at 48 weeks PubMed
  • Semaglutide strong weight loss and metabolic effects PubMed
  • MOTS-c improves metabolic homeostasis via AMPK PubMed

Injury Recovery Stack

Accelerate healing of musculoskeletal injuries including tendons, ligaments, muscles, and post-surgical recovery

Stack Compounds

BPC-157Primary tissue repair driver promotes angiogenesis, collagen deposition, and growth factor upregulation at injury sites
TB-500Complements BPC-157 by promoting cell migration via actin upregulation and reducing fibrotic scar formation
KPVPotent anti-inflammatory suppresses NF-κB signaling to create optimal healing environment
SS-31Protects mitochondria in stressed/injured cells, ensuring energy supply for tissue repair

Why It Works

Synergistic repair + anti-inflammation + mitochondrial support. BPC-157 and TB-500 work through distinct but complementary repair mechanisms. KPV reduces the inflammatory cascade that impedes healing. SS-31 ensures damaged cells maintain energy production needed for repair.

Key Studies

  • BPC-157 tendon, ligament, and gut healing effects PubMed
  • TB-500 wound healing and inflammation reduction PubMed
  • SS-31 improves mitochondrial function in clinical trials PubMed

Mental Clarity & Cognitive Stack

Enhance focus, memory, learning capacity, neurogenesis, and neuroprotection

Stack Compounds

SemaxPrimary nootropic BDNF upregulation for enhanced neural plasticity, memory, and focus
SelankReduces anxiety-related cognitive interference via GABA modulation without sedation
DihexaUltra-potent HGF mimetic promoting synaptogenesis and neurogenesis the cognitive amplifier

Why It Works

Neurotrophic/nootropic synergy: Semax enhances BDNF for learning and plasticity, Selank clears anxiety-based cognitive interference, and Dihexa drives new synapse formation. Together they address cognitive acquisition (Semax), emotional interference (Selank), and structural brain enhancement (Dihexa).

Key Studies

  • Semax improves cognition in human trials PubMed
  • Selank anxiolytic effects in humans PubMed
  • Dihexa cognitive benefits in preclinical models PubMed

Muscle Growth Stack

Maximize lean muscle gain through GH optimization, growth factor signaling, and myostatin inhibition

Stack Compounds

CJC-1295Sustained GH release for anabolic environment and protein synthesis
IpamorelinSelective GH amplifier without cortisol the cleanest GH secretagogue
SermorelinNatural GH pulse stimulation proven to increase lean mass in clinical trials
Follistatin-344Blocks myostatin to remove the body's natural ceiling on muscle growth
IGF-1 LR3Drives muscle cell hyperplasia (new fiber creation) beyond normal hypertrophy

Why It Works

Multi-pathway anabolic stack: GH peptides (CJC/Ipamorelin/Sermorelin) create the hormonal environment, Follistatin removes the myostatin brake, and IGF-1 LR3 drives new muscle cell creation. This addresses all three growth limiters simultaneously.

Key Studies

  • CJC-1295 sustained GH/IGF-1 elevations PubMed
  • Sermorelin increases lean mass in older adults PubMed
  • IGF-1 promotes muscle in models PubMed

Immune Support Stack

Strengthen and modulate immune function for enhanced pathogen defense

Stack Compounds

Thymosin Alpha-1Primary immune enhancer matures T-cells, activates dendritic cells, modulates cytokine balance
SelankSupports balanced immune gene expression and reduces stress-related immunosuppression
BPC-157Anti-inflammatory support and mucosal barrier protection first line of immune defense

Why It Works

Thymosin Alpha-1 directly enhances immune cell function. Selank reduces the immunosuppressive effects of chronic stress. BPC-157 protects mucosal barriers (where 70% of immune cells reside). Combined: active immunity + stress protection + barrier integrity.

Key Studies

  • Thymosin Alpha-1 in immune-compromised patients PubMed
  • Selank anxiolytic and immune effects PubMed
  • BPC-157 gut healing effects PubMed

Deep Sleep & Recovery Stack

Optimize sleep quality, enhance nightly recovery, and improve hormonal output during sleep

Stack Compounds

DSIPDirectly promotes delta-wave (deep) sleep phases critical for recovery
IpamorelinEnhances natural nighttime GH surge for improved overnight tissue repair
EpitalonSupports melatonin production and circadian rhythm regulation via pineal gland
SelankReduces anxiety and racing thoughts that interfere with sleep onset

Why It Works

DSIP targets delta-wave sleep directly. Epitalon supports melatonin production for circadian timing. Selank addresses the anxiety component disrupting sleep onset. Ipamorelin amplifies the natural nighttime GH pulse, turning better sleep into better recovery.

Key Studies

  • DSIP promotes delta sleep in models PubMed
  • Ipamorelin selective GH release PubMed
  • Epitalon lifespan and neuroendocrine effects PubMed

Longevity & Anti-Aging Stack

Target fundamental aging mechanisms: telomeres, mitochondria, metabolism, and cellular protection

Stack Compounds

EpitalonActivates telomerase to maintain telomere length addresses cellular aging at the chromosomal level
MOTS-cAMPK-mediated metabolic optimization combats age-related metabolic decline
SS-31Stabilizes mitochondrial membranes addresses the energy crisis of aging cells
GHK-CuResets gene expression toward younger patterns across 4,000+ genes

Why It Works

Multi-hallmark anti-aging approach: Epitalon targets telomere attrition, MOTS-c and SS-31 target mitochondrial dysfunction through complementary mechanisms, and GHK-Cu broadly shifts gene expression toward regeneration.

Key Studies

  • Epitalon extends lifespan in animal models PubMed
  • MOTS-c improves metabolic homeostasis PubMed
  • GHK-Cu skin regeneration PubMed

Skin & Aesthetic Rejuvenation Stack

Improve skin quality, texture, elasticity, and promote hair growth

Stack Compounds

GHK-CuCore skin peptide stimulates collagen, elastin, and glycosaminoglycan synthesis
BPC-157Enhances blood vessel formation for improved skin nourishment and healing
EpitalonAddresses cellular senescence in skin cells via telomerase activation

Why It Works

GHK-Cu rebuilds the extracellular matrix (structure), BPC-157 enhances vascularity (nourishment), and Epitalon addresses cellular aging (longevity of skin cells).

Key Studies

  • GHK-Cu promotes skin regeneration PubMed
  • BPC-157 tissue healing effects PubMed
  • Epitalon telomerase activation PubMed

Gut Health & Recovery Stack

Repair and protect the gastrointestinal lining and reduce GI inflammation

Stack Compounds

BPC-157Primary gut-healing peptide derived from gastric juice, repairs mucosal damage from NSAIDs, stress, and inflammation
KPVPotent NF-κB suppressor specifically effective for intestinal inflammation and IBD models
Thymosin Alpha-1Modulates gut-associated immune tissue (GALT) for balanced intestinal immune response

Why It Works

BPC-157 directly heals gut lining. KPV suppresses the inflammatory pathways driving intestinal damage. Thymosin Alpha-1 balances the gut immune system. Together: repair + anti-inflammation + immune balance.

Key Studies

  • BPC-157 gut healing effects PubMed
  • KPV anti-inflammatory activity PubMed
  • Thymosin Alpha-1 immune modulation PubMed

Metabolic & Insulin Sensitivity Stack

Improve metabolic health, insulin sensitivity, and cellular energy production

Stack Compounds

TirzepatideFDA-approved dual agonist gold standard for glycemic control and metabolic improvement
MOTS-cAMPK activator for enhanced glucose uptake and fatty acid oxidation at the cellular level
TesamorelinReduces visceral fat (a primary driver of insulin resistance) with strong clinical evidence
SS-31Restores mitochondrial efficiency the root cause of metabolic dysfunction

Why It Works

Tirzepatide provides the strongest clinical metabolic improvement. MOTS-c addresses AMPK signaling. Tesamorelin removes visceral fat driving inflammation. SS-31 fixes the mitochondrial dysfunction underlying metabolic disease.

Key Studies

  • Tirzepatide Phase 3 metabolic outcomes PubMed
  • MOTS-c metabolic homeostasis PubMed
  • Tesamorelin visceral fat reduction PubMed

Hormonal Optimization Stack (Male)

Support healthy testosterone levels and hormonal balance while preserving fertility

Stack Compounds

CJC-1295Supports GH axis which synergizes with testosterone signaling for anabolic environment
IpamorelinSelective GH without cortisol chronic cortisol suppresses testosterone production
SermorelinNatural GH pulse mimicry proven clinical lean mass and recovery benefits

Why It Works

GH optimization supports testosterone's anabolic effects. CJC-1295 and Ipamorelin paired across two different receptor systems for amplified GH. Sermorelin adds physiologic GH pulsing. The avoidance of cortisol spikes (Ipamorelin's key advantage) protects the HPG axis.

Key Studies

  • CJC-1295 sustained GH/IGF-1 elevations PubMed
  • Ipamorelin selective GH release PubMed
  • Sermorelin lean mass benefits PubMed