AOD-9604 vs Cagrilintide.
Quick Verdict
AOD-9604 is a gh fragment primarily researched for fat loss without gh side effects, while Cagrilintide is a metabolic studied for weight loss, appetite reduction, glycemic control.
Side-by-Side Analysis
| Dimension | AOD-9604 | Cagrilintide |
|---|---|---|
| Category | GH Fragment | Metabolic |
| Mechanism | Mimics GH fat-burning domain. | Long-acting amylin analog that activates amylin receptors in the area postrema and hypothalamus to reduce appetite, slow gastric emptying, and suppress post-meal glucagon secretion. |
| Half-Life | ~1 hours | ~7 days |
| Route | SubQ | SubQ |
| Typical Dose | 300–300 mcg | 500–4500 mcg |
| Frequency | 7x/wk | Weekly |
| Evidence Level | Preclinical | Strong |
| Indexed Studies | 18+ indexed | 20+ indexed |
| FDA Status | Research Only | Research Only |
| Lowest Price | $49.99 / 5mg via Amino Club | $69.99 / 10mg via Amino Club |
| Per-mg Cost | $10.00/mg | $7.00/mg |
Mechanism of Action Comparison
How AOD-9604 Works
AOD-9604 AOD-9604 is a synthetic fragment of human growth hormone studied for its ability to burn fat without the blood sugar or growth side effects of full GH.
Mimics GH fat-burning domain. Stimulates lipolysis and inhibits lipogenesis by acting on beta-3 adrenergic receptors in fat tissue, without binding to the GH receptor.
How Cagrilintide Works
Cagrilintide Cagrilintide is a long-acting amylin analog investigated for weight loss, studied in Phase 2 trials for achieving over 10% body weight reduction when combined with semaglutide.
Long-acting amylin analog that activates amylin receptors in the area postrema and hypothalamus to reduce appetite, slow gastric emptying, and suppress post-meal glucagon secretion. Works on a distinct pathway from GLP-1 agonists, making it ideal for combination therapy.
Key Mechanistic Difference
AOD-9604 operates as a gh fragment, while Cagrilintide functions as a metabolic — these are fundamentally different pharmacological approaches. Cagrilintide has a significantly longer half-life (~7 days) compared to AOD-9604 (~1 hours), which impacts dosing frequency and sustained activity.
Research Evidence
AOD-9604
18 studies- AOD-9604 lipolysis stimulation in preclinical modelsNg et al. demonstrate AOD-9604 stimulates lipolysis and inhibits lipogenesis in adipose tissue without affecting IGF-1 o…Preclinical
- AOD-9604 clinical safety six randomized controlled trialsHeffernan et al.: Pooled analysis of 6 RCTs showing AOD-9604 is well-tolerated with a safety profile similar to placebo …Moderate
- AOD-9604 Phase IIb trial short-term fat reduction12-week Phase IIb trial: 1mg/day AOD-9604 produced 2.6 kg weight loss vs 0.8 kg placebo, with reductions in abdominal fa…Moderate
Cagrilintide
20 studies- Cagrilintide Phase 2 trial for weight managementLau et al. (Lancet): Phase 2 RCT showing cagrilintide 4.5mg weekly achieved 10.8% weight loss vs 3.0% placebo at 26 week…Strong
- CagriSema (cagrilintide + semaglutide) Phase 2 resultsFrias et al. (Lancet): CagriSema combination achieved 15.6% weight loss at 32 weeks in type 2 diabetes patients — superi…Strong
- Amylin analogs in obesity management: mechanism reviewReview of amylin's role in energy homeostasis and why dual amylin-calcitonin receptor agonists like cagrilintide represe…Moderate
Vendor Pricing
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Frequently Asked Questions
Can I take AOD-9604 and Cagrilintide together?▼
No direct interaction data is available for this specific pair. They target different receptor systems, suggesting they could potentially be combined, but no published protocol validates this combination.
Which has more research evidence — AOD-9604 or Cagrilintide?▼
AOD-9604 has 18 indexed studies (highest evidence: Preclinical). Cagrilintide has 20 indexed studies (highest evidence: Strong). Cagrilintide has a more extensive research base.
What is the price difference between AOD-9604 and Cagrilintide?▼
At current verified vendor prices, Cagrilintide starts at $7.00/mg while AOD-9604 starts at $10.00/mg. Prices vary by vendor and vial size — see the full vendor comparison below.
Which is better for fat loss — AOD-9604 or Cagrilintide?▼
Both are researched for fat loss. AOD-9604 addresses this via fat loss without gh side effects. Cagrilintide approaches it through weight loss, appetite reduction, glycemic control. The optimal choice depends on your specific research protocol and which mechanism aligns with your objectives.
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Research Use Only — Not Medical Advice
This comparison is provided for educational and research purposes only. It does not constitute medical, prescribing, or treatment advice. Clinical data cited here is sourced from published peer-reviewed trials and FDA labels. Consult a qualified healthcare professional before making any decisions about medications or research compounds. PeptiDex is an informational resource and does not sell pharmaceutical products.