Overview
5-Amino-1MQ is classified as a nnmt inhibitor peptide. Fat loss, NAD+ preservation, metabolic optimization, muscle protection.
Selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that consumes SAM and depletes NAD+ pools while promoting fat storage. By blocking NNMT, 5-Amino-1MQ raises intracellular NAD+ levels, activates SIRT1, and shifts adipocytes toward lipolysis. Shown in rodent models to reduce fat mass without caloric restriction.
Also known as: 5-amino-1-methylquinolinium, 5A1MQ
Category
NNMT Inhibitor
Half-Life
2h
Route
Oral
FDA Status
Not Approved
How Does 5-Amino-1MQ Work?
Selectively inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that consumes SAM and depletes NAD+ pools while promoting fat storage. By blocking NNMT, 5-Amino-1MQ raises intracellular NAD+ levels, activates SIRT1, and shifts adipocytes toward lipolysis. Shown in rodent models to reduce fat mass without caloric restriction.
At the molecular level, 5-Amino-1MQ operates through pathways characteristic of the NNMT Inhibitor class, interacting with target receptors and downstream signaling cascades to produce its observed effects.
Published Research
The following studies are indexed from PubMed and peer-reviewed journals:
[1]NNMT inhibition induces browning of white adipose tissue and reduces fat mass
Neelakantan et al. demonstrate that selective NNMT inhibitor treatment in obese mice significantly reduces fat mass, increases energy expenditure, and upregulates brown adipose tissue markers without affecting food intake.
Evidence: preclinical[2]NNMT inhibition protects against diet-induced obesity
Kraus et al. (Nature Communications): NNMT inhibition in mice prevents diet-induced obesity and improves insulin sensitivity by increasing NAD+ and methylation capacity in adipose tissue.
Evidence: preclinicalSafety Profile
⚠ PRECLINICAL RESEARCH ONLY. No completed human clinical trials. All efficacy and safety data derived from rodent models. Do not extrapolate to human dosing. Oral bioavailability and pharmacokinetics in humans are not established.
| Side Effect | Incidence | Severity |
|---|---|---|
| Unknown in humans | Not established | rare |
Sourcing 5-Amino-1MQ for Research
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Full Research Profile
5-Amino-1MQ — dosing, interactions, timelines & more
Comprehensive compound profile with sourcing information, stacking synergies, and outcome timelines.