Overview
FGL Loop is classified as a neurotropic peptide peptide. Synaptogenesis, memory enhancement, NCAM-mediated neuroprotection.
Synthetic peptide derived from the fibronectin type III (F3) module of Neural Cell Adhesion Molecule (NCAM). Mimics the homophilic binding of NCAM, activating FGFR (fibroblast growth factor receptor) signaling downstream, which promotes synaptogenesis, long-term potentiation (LTP), and memory consolidation. In rodent models improves spatial memory and reduces age-related synaptic loss.
Also known as: NCAM FGL peptide, Fibroblast Growth Factor Loop, FGL
Category
Neurotropic Peptide
Route
SubQ
FDA Status
Not Approved
How Does FGL Loop Work?
Synthetic peptide derived from the fibronectin type III (F3) module of Neural Cell Adhesion Molecule (NCAM). Mimics the homophilic binding of NCAM, activating FGFR (fibroblast growth factor receptor) signaling downstream, which promotes synaptogenesis, long-term potentiation (LTP), and memory consolidation. In rodent models improves spatial memory and reduces age-related synaptic loss.
At the molecular level, FGL Loop operates through pathways characteristic of the Neurotropic Peptide class, interacting with target receptors and downstream signaling cascades to produce its observed effects.
Published Research
The following studies are indexed from PubMed and peer-reviewed journals:
[1]FGL peptide promotes synaptogenesis and memory via NCAM/FGFR signaling
Cambon et al.: FGL peptide enhances LTP in hippocampal slices and improves spatial learning in rodents via FGFR-dependent synaptogenesis, establishing NCAM-mimetic peptides as cognitive enhancers.
Evidence: preclinical[2]NCAM mimetics as neuroprotective agents in aging and neurodegeneration
Review of NCAM-derived peptides including FGL, documenting their capacity to promote synaptogenesis, neuroprotection, and memory retention in animal models of aging and neurodegeneration.
Evidence: preclinicalSafety Profile
⚠ PRECLINICAL RESEARCH ONLY. No completed human clinical trials. All data from rodent models. No established human pharmacokinetics, dosing protocol, or safety profile. Research use only.
| Side Effect | Incidence | Severity |
|---|---|---|
| Unknown in humans | Not established | rare |
Sourcing FGL Loop for Research
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Full Research Profile
FGL Loop — dosing, interactions, timelines & more
Comprehensive compound profile with sourcing information, stacking synergies, and outcome timelines.