Overview
OS-01 is classified as a cosmetic peptide peptide. Skin cellular age reversal, senescent skin cell clearance, photoaging repair, epidermal renewal.
Proprietary 8-amino acid peptide developed by OneSkin Technologies. Activates p53-mediated clearance of senescent skin cells in the epidermis and dermis. Reduces markers of cellular senescence (p21, p16) in keratinocytes and fibroblasts, promotes renewal of the epidermal skin cell population, and reduces UV-induced DNA damage accumulation. Applied topically — NOT for injection. OneSkin has published peer-reviewed data demonstrating reversal of skin's biological age via methylation clock analysis.
Also known as: OneSkin OS-01 peptide, p53-activating peptide
Category
Cosmetic Peptide
Route
Topical
FDA Status
Not Approved
How Does OS-01 Work?
Proprietary 8-amino acid peptide developed by OneSkin Technologies. Activates p53-mediated clearance of senescent skin cells in the epidermis and dermis. Reduces markers of cellular senescence (p21, p16) in keratinocytes and fibroblasts, promotes renewal of the epidermal skin cell population, and reduces UV-induced DNA damage accumulation. Applied topically — NOT for injection. OneSkin has published peer-reviewed data demonstrating reversal of skin's biological age via methylation clock analysis.
At the molecular level, OS-01 operates through pathways characteristic of the Cosmetic Peptide class, interacting with target receptors and downstream signaling cascades to produce its observed effects.
Published Research
The following studies are indexed from PubMed and peer-reviewed journals:
Safety Profile
TOPICAL USE ONLY. Not for injection. This is a cosmetic/skincare peptide in a topical formulation — not a research injectable. No reconstitution required. Available commercially via OneSkin (oneskin.co). Excellent topical safety profile. Not FDA-approved as a drug.
| Side Effect | Incidence | Severity |
|---|---|---|
| Mild skin sensitivity | Rare | mild |
Sourcing OS-01 for Research
If you're looking to source OS-01 for laboratory research, our vendor directory compares pricing, purity testing, and COA verification from independently vetted suppliers.
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Full Research Profile
OS-01 — dosing, interactions, timelines & more
Comprehensive compound profile with sourcing information, stacking synergies, and outcome timelines.