What Is OS-01?

OS-01 is classified as a cosmetic peptide peptide. Skin cellular age reversal, senescent skin cell clearance, photoaging repair, epidermal renewal.

Proprietary 8-amino acid peptide developed by OneSkin Technologies. Activates p53-mediated clearance of senescent skin cells in the epidermis and dermis. Reduces markers of cellular senescence (p21, p16) in keratinocytes and fibroblasts, promotes renewal of the epidermal skin cell population, and reduces UV-induced DNA damage accumulation. Applied topically — NOT for injection. OneSkin has published peer-reviewed data demonstrating reversal of skin's biological age via methylation clock analysis.

Also known as: OneSkin OS-01 peptide, p53-activating peptide

Proprietary 8-amino acid peptide developed by OneSkin Technologies. Activates p53-mediated clearance of senescent skin cells in the epidermis and dermis. Reduces markers of cellular senescence (p21, p16) in keratinocytes and fibroblasts, promotes renewal of the epidermal skin cell population, and reduces UV-induced DNA damage accumulation. Applied topically — NOT for injection. OneSkin has published peer-reviewed data demonstrating reversal of skin's biological age via methylation clock analysis.

At the molecular level, OS-01 operates through pathways characteristic of the Cosmetic Peptide class, interacting with target receptors and downstream signaling cascades to produce its observed effects.

TOPICAL USE ONLY. Not for injection. This is a cosmetic/skincare peptide in a topical formulation — not a research injectable. No reconstitution required. Available commercially via OneSkin (oneskin.co). Excellent topical safety profile. Not FDA-approved as a drug.