Also known as: Ala-Glu-Asp-Pro, AEDP
Cortagen is a khavinson peptide research compound (not FDA-approved for human use) studied for neuroregeneration. Cortagen is a Russian-developed tetrapeptide that enters nerve cell nuclei to regulate gene expression, studied for neuroregeneration after injury and cardiac tissue protection. Research dose: 5–10 mg daily x 10 days. Half-life: not established. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Rankings independent · Research use only
Synthetic tetrapeptide (Ala-Glu-Asp-Pro) Khavinson bioregulatory peptide with tissue-specific regulatory activity in cortical and peripheral nerve tissue. Penetrates cell nuclei, modulates gene expres
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
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| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
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Cortagen (also known as Ala-Glu-Asp-Pro, AEDP) is a prominently researched experimental compound classified strictly within the Khavinson Peptide framework. Operating primarily through advanced pharmacological pathways, its core mechanism of action is as follows: it synthetic tetrapeptide (Ala-Glu-Asp-Pro) Khavinson bioregulatory peptide with tissue-specific regulatory activity in cortical and peripheral nerve tissue. Penetrates cell nuclei, modulates gene expression profiles associated with neuroregeneration, and stimulates differentiation of neuronal progenitor cells. Also documented with cardioprotective effects via modulation of cardiac gene expression. with an established metabolic degradation profile, In preclinical investigative trials and independent academic studies, researchers utilizing Cortagen have documented significant, quantifiable biological outcomes, primarily focusing on neuroregeneration, peripheral nerve repair, cardiac protection, anti-aging. Typical research protocols investigate administering 5000 to 10000mcg via subq pathways daily x 10 days. However, it is critically important to understand that while Cortagen demonstrates profound physiological potential in highly controlled laboratory settings, it remains classified strictly as a research chemical and has not been approved by the United States Food and Drug Administration (FDA) for human therapeutic, diagnostic, or dietary consumption. Independent chemical analysis via rigorous third-party Certificate of Analysis (COA) testing utilizing High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) remains the industry gold standard for verifying its base elemental stability when reconstituted appropriately in sterile bacteriostatic water.
Synthetic tetrapeptide (Ala-Glu-Asp-Pro) Khavinson bioregulatory peptide with tissue-specific regulatory activity in cortical and peripheral nerve tissue. Penetrates cell nuclei, modulates gene expression profiles associated with neuroregeneration, and stimulates differentiation of neuronal progenitor cells. Also documented with cardioprotective effects via modulation of cardiac gene expression.
Khavinson et al.: Cortagen demonstrates neuroprotective effects in a rat cortical neuron ischemia model by modulating gene expression and reducing apoptosis in damaged neuronal tissue.
PreclinicalKhavinson et al.: Cortagen modulates cardiac gene expression and reduces myocardial injury markers in rodent ischemia models, suggesting a cardioprotective role.
Preclinical⚠ PRECLINICAL RESEARCH ONLY. Based entirely on Khavinson group publications. No Western clinical trials. Not FDA-approved. Research only. Limited reproducibility data outside the originating research group.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.
Khavinson peptide protocol: short-course administration 1–2x per year. No validated Western protocol.
Week 1
Neuroprotective marker changes in preclinical models
| Side Effect | Incidence | Severity |
|---|---|---|
Injection site reaction | Rare | mild |
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⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
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