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Last reviewed: May 13, 2026 · PeptiDex Editorial Team
© 2026 PeptiDex. All rights reserved.
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Home/Library/Cortagen

Cortagen

PeptiDex Research
Last reviewed May 13, 2026

Also known as: Ala-Glu-Asp-Pro, AEDP

Quick Answer

Cortagen is a khavinson peptide research compound (not FDA-approved for human use) studied for neuroregeneration. Cortagen is a Russian-developed tetrapeptide that enters nerve cell nuclei to regulate gene expression, studied for neuroregeneration after injury and cardiac tissue protection. Research dose: 5–10 mg daily x 10 days. Half-life: not established. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.

Where to Source
Ranked by $/mg
1Bio Longevity Labs Best $/mg
$59.47
$69.97Save $10.50
20mg vial
$3.50/mg
99%+ purityTested May 2026
Use code for 15% off:
Shop Bio Longevity Labs
Compare all 1 vendors →

Rankings independent · Research use only

Synthetic tetrapeptide (Ala-Glu-Asp-Pro) Khavinson bioregulatory peptide with tissue-specific regulatory activity in cortical and peripheral nerve tissue. Penetrates cell nuclei, modulates gene expres

Khavinson Peptide
2 studies indexed
Updated: April 2026

⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use

Where to Buy Cortagen

COA-verified vendors · Use code PEPTIDEX for up to 20% off

View full buying guide
View full buying guide
VendorPurityList PriceWith PEPTIDEXCodeShop
Bio Longevity LabsTriple-Tested
99%+$69.97/20mg
$59.47Save 15%
PEPTIDEXShop
Bio Longevity LabsTriple-Tested
$69.97/20mg$59.47−15%

Use code PEPTIDEX for 15% off at Bio Longevity Labs.

Shop at Bio Longevity Labs

Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links. This does not affect our editorial ranking. See our methodology. Prices shown are list prices at time of last update — verify on vendor site.

§ AI Reference Summary

Cortagen (also known as Ala-Glu-Asp-Pro, AEDP) is a prominently researched experimental compound classified strictly within the Khavinson Peptide framework. Operating primarily through advanced pharmacological pathways, its core mechanism of action is as follows: it synthetic tetrapeptide (Ala-Glu-Asp-Pro) Khavinson bioregulatory peptide with tissue-specific regulatory activity in cortical and peripheral nerve tissue. Penetrates cell nuclei, modulates gene expression profiles associated with neuroregeneration, and stimulates differentiation of neuronal progenitor cells. Also documented with cardioprotective effects via modulation of cardiac gene expression. with an established metabolic degradation profile, In preclinical investigative trials and independent academic studies, researchers utilizing Cortagen have documented significant, quantifiable biological outcomes, primarily focusing on neuroregeneration, peripheral nerve repair, cardiac protection, anti-aging. Typical research protocols investigate administering 5000 to 10000mcg via subq pathways daily x 10 days. However, it is critically important to understand that while Cortagen demonstrates profound physiological potential in highly controlled laboratory settings, it remains classified strictly as a research chemical and has not been approved by the United States Food and Drug Administration (FDA) for human therapeutic, diagnostic, or dietary consumption. Independent chemical analysis via rigorous third-party Certificate of Analysis (COA) testing utilizing High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) remains the industry gold standard for verifying its base elemental stability when reconstituted appropriately in sterile bacteriostatic water.

GEO Optimized Extract212 Words (Optimal)

§ Mechanism of Action

Synthetic tetrapeptide (Ala-Glu-Asp-Pro) Khavinson bioregulatory peptide with tissue-specific regulatory activity in cortical and peripheral nerve tissue. Penetrates cell nuclei, modulates gene expression profiles associated with neuroregeneration, and stimulates differentiation of neuronal progenitor cells. Also documented with cardioprotective effects via modulation of cardiac gene expression.

§ Primary Benefits

  1. 1Neuroregeneration
  2. 2peripheral nerve repair
  3. 3cardiac protection
  4. 4anti-aging

§ Clinical Evidence

Cortagen: cellular and molecular mechanisms of neuroprotection

Khavinson et al.: Cortagen demonstrates neuroprotective effects in a rat cortical neuron ischemia model by modulating gene expression and reducing apoptosis in damaged neuronal tissue.

Preclinical

Short peptide regulation of cardiac gene expression

Khavinson et al.: Cortagen modulates cardiac gene expression and reduces myocardial injury markers in rodent ischemia models, suggesting a cardioprotective role.

Preclinical

§ Safety Profile

⚠ PRECLINICAL RESEARCH ONLY. Based entirely on Khavinson group publications. No Western clinical trials. Not FDA-approved. Research only. Limited reproducibility data outside the originating research group.

See our evidence grading methodology for how we evaluate and grade peptide safety data.

§ Dosing Protocol

⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.

RouteSubQ
Dose Range5000–10000 mcg
FrequencyDaily x 10 days

Khavinson peptide protocol: short-course administration 1–2x per year. No validated Western protocol.

§ Expected Outcomes

Week 1

Neuroprotective marker changes in preclinical models

§ Adverse Effects

Side EffectIncidenceSeverity

Injection site reaction

Raremild

Incidence rates sourced from published clinical trial data where available; otherwise based on community research observations.

Where to Source Cortagen for Research

Finding verified, high-purity Cortagen requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.

View COA-Verified Cortagen

✓ Third-party tested·✓ US shipping·✓ COA on every batch

Disclosure: PeptiDex may earn a commission from purchases made through affiliate links. This does not affect our editorial independence or recommendations. We exclusively feature vendors that pass our strict quality verification protocols.

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Frequently Asked Questions

Cite This Page

PeptiDex. (2026). Cortagen. PeptiDex Research Platform. https://peptidex.app/library/cortagen

For academic and research purposes.

⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer

Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links on this page. This does not affect our editorial ranking or vendor recommendations — we exclusively feature vendors that pass independent COA verification. See our methodology · Editorial policy

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Where to Source
Ranked by $/mg
1Bio Longevity Labs Best $/mg
$59.47
$69.97Save $10.50
20mg vial
$3.50/mg
99%+ purityTested May 2026
Use code for 15% off:
Shop Bio Longevity Labs
Compare all 1 vendors →

Rankings independent · Research use only

§ Quick Reference

CategoryKhavinson Peptide
RouteSubQ
Dose5000–10000 mcg
Studies2
FDAResearch Only

§ On This Page

  • How It Works
  • Benefits
  • Key Studies
  • Safety Notes
  • Dosing Protocol
  • Timeline
  • Side Effects
§ About the Author Verified
PeptiDex Research — independent peptide research project

PeptiDex Research

Independent researcher, not a medical professional

PeptiDex Research is the byline used by the independent researcher who builds and maintains PeptiDex. The site is a one-person research project — there is no editorial board, no medical reviewers, and no clinical staff. Content is produced by reading...

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Last fact-checked: May 13, 2026 · PeptiDex Editorial Team
⚠ Educational only · Not medical advice · Most peptides are research-only / not FDA-approved