⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use

Dihexa

ðŸ§ Neurotrophic

How It Works

HGF mimetic. Potently activates the hepatocyte growth factor (HGF) system to promote synaptogenesis and neurogenesis. Estimated 10 million times more potent than BDNF.

Primary Benefits

1Cognitive enhancement

2neurogenesis

Key Studies

Dihexa procognitive/anti-dementia properties via HGF/c-Met

McCoy et al. (J. Pharmacol. Exp. Ther.): Dihexa improves spatial learning and working memory at very low doses by potentiating HGF/c-Met signaling, increasing dendritic spine density.

preclinical

Dihexa restores cognition in Alzheimer's mouse model (APP/PS1)

In APP/PS1 Alzheimer's mice, Dihexa restored spatial learning, increased neuronal cells, reduced neuroinflammation, and activated PI3K/AKT signaling pathway.

preclinical

Angiotensin IV-derived cognitive enhancers mechanism review

Wright & Harding review the AT4 receptor system and HGF/c-Met-mediated synaptogenesis that underlies Dihexa's extraordinary cognitive-enhancing potency.

preclinical

Safety Notes

Limited human data. Extremely potent dose sensitivity critical. HGF/c-Met activation raises theoretical tumorigenic concerns. Research-only.

Dosing Protocol

⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.

RouteOral

Dose Range5000-20000 mcg

FrequencyDaily

TimingMorning

Cycle Length4-8 weeks

Oral bioavailability. Often taken sublingually. Start extremely low. Very potent at microgram levels.

Half-Life Visualization

⏱️ Half-Life: 30min

Plasma concentration over time

Legal Status by Country

🇺🇸USA

Research Only

🇨🇦Canada

Research Only

🇬🇧UK

Unregulated

🇪🇺EU

Unregulated

🇦🇺Australia

Research Only

Last updated: 2026-01 · Laws change frequently. Verify current status in your jurisdiction.

Expected Timeline

Week 1

Cognitive enhancement reported; improved recall and processing speed

Weeks 2-4

Neurogenesis support; improved executive function and mood

Month 2-3

Cumulative cognitive gains; improved performance on memory tasks (preclinical)

Long-term

Limited long-term human data; theoretical concerns around HGF/c-Met activation

Side Effects & Incidence

Side Effect	Incidence	Severity
Limited human data	Dose sensitivity critical	mild
Mood changes	Variable	mild
Theoretical cardiovascular effects HGF/c-Met activation; no confirmed human reports	Mechanism-based concern	rare

Side Effect

Incidence

Severity

Limited human data

Dose sensitivity critical

mild

Mood changes

Variable

mild

Theoretical cardiovascular effects

HGF/c-Met activation; no confirmed human reports

Mechanism-based concern

rare

Incidence rates sourced from published clinical trial data where available; otherwise based on community research observations.

Found in 1 Stack

Mental Clarity & Cognitive Stack

Enhance focus, memory, learning capacity, neurogenesis, and neuroprotection

Semax Selank Dihexa

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