GHRP-2
Last reviewed May 27, 2026
Also known as: Growth Hormone Releasing Peptide-2, Pralmorelin, KP-102
Quick Answer
GHRP-2 is a ghrp research compound (not FDA-approved for human use) studied for strongest gh release of standard ghrps. GHRP-2 is a synthetic growth-hormone-releasing peptide studied for producing strong GH pulses, approved in Japan as a diagnostic tool for detecting growth hormone deficiency. Research dose: 100–300 mcg 1-3x daily. Half-life: 1.5 hours. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
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Ranked by $/mg1Amino Club Best $/mg
$69.59
$86.99Save $17.40
5mg vial
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99%+ purityCOA · Apr 2026
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Rankings independent · Research use only
Synthetic hexapeptide GH secretagogue acting on the GHSR1a receptor. GHRP-2 produces the most potent GH release among standard GHRPs (stronger than GHRP-6 or Ipamorelin) but with moderate increases in
Where to Buy GHRP-2
COA-verified vendors · Use code PEPTIDEX for up to 20% off
* Prices for research peptide acquisition. Not therapeutic products.
| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
| 99%+ | $86.995 mg | $69.59Save 20% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop | |
| 99%+ | $97.005 mg | $82.45Save 15% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop |
$86.99 · 5 mg$69.59−20%
Use code PEPTIDEX for 20% off at Amino Club.
* Research vendor — verify your regional regulations before purchase.
Shop at Amino Club$97.00 · 5 mg$82.45−15%
Use code PEPTIDEX for 15% off at Limitless Life.
* Research vendor — verify your regional regulations before purchase.
Shop at Limitless Life§ Mechanism of Action
Synthetic hexapeptide GH secretagogue acting on the GHSR1a receptor. GHRP-2 produces the most potent GH release among standard GHRPs (stronger than GHRP-6 or Ipamorelin) but with moderate increases in cortisol and prolactin. Approved in Japan as a diagnostic tool for GH deficiency (trade name: Pralmorelin/GHRP Kaken).
§ Primary Benefits
- 1Strongest GH release of standard GHRPs
- 2muscle growth
- 3anti-aging
- 4recovery
§ Clinical Evidence
GHRP-2 potent GH release in healthy adults
Arvat et al. (J. Clin. Endocrinol. Metab.): GHRP-2 produces the strongest GH response among tested GHRPs in healthy adults, with dose-dependent effects and moderate prolactin/cortisol elevation.
ModerateGHRP-2 approved diagnostic agent for GH deficiency
Clinical validation of GHRP-2 (Pralmorelin) as a diagnostic GH provocative test in Japan, showing reliable, reproducible GH stimulation for diagnosing adult GH deficiency.
StrongGHRP-2 effects on sleep and nocturnal GH secretion
Frieboes et al.: GHRP-2 enhances slow-wave sleep and amplifies nocturnal GH pulses in healthy young men, supporting pre-bed dosing protocols.
ModerateGHRP-2 increases IGF-1 and lean mass in elderly
Bowers et al.: Chronic GHRP-2 administration in elderly subjects increases IGF-1, GH, and lean body mass while reducing fat mass.
ModeratePossible Involvement of Hypothalamic Dysfunction in Long COVID Patients Characterized by Delayed Response to Gonadotropin-Releasing Hormone.
A 2026 study found that long COVID patients exhibited delayed hormonal responses to gonadotropin-releasing hormone, while growth hormone responses to GHRP-2 stimulation remained preserved. These findings suggest functional secondary hypothalamic dysfunction rather than irreversible primary pituitary injury.
ModerateDiurnal and Daily Variations in Growth Hormone and Growth Hormone Stimulation Test in Male Cynomolgus Monkeys.
In a 2026 study, researchers demonstrated that cynomolgus monkeys exhibit diurnal growth hormone variations similar to humans and respond significantly to exogenous GHRH. These findings confirmed that morning GHRH stimulation reliably assesses growth hormone levels, validating this animal model for pituitary toxicity research.
PreclinicalOne Case of Sudden Isolated Adrenocorticotropic Hormone (ACTH) Deficiency Diagnosed Based on Repeated Hypoglycemic Attacks.
A 2025 case report demonstrated that a growth hormone-releasing peptide-2 (GHRP-2) load test helped diagnose sudden isolated ACTH deficiency in a patient experiencing severe hypoglycemia. The peptide was utilized alongside other stimulation tests to evaluate specific pituitary functions.
AnecdotalBenchmark for Setting ACTH Cell Dosage in Clinical Regenerative Medicine for Post-Operative Hypopituitarism.
A 2025 study found that the average peak secretion values for ACTH and GH in human patients were 97.2 pg/mL and 25.1 ng/mL, respectively. These findings established critical benchmarks for determining safe cell dosages in future regenerative pituitary transplantations.
ModerateGrowth Hormone-Releasing Peptide 2 May Be Associated With Decreased M1 Macrophage Production and Increased Histologic and Biomechanical Tendon-Bone Healing Properties in a Rat Rotator Cuff Tear Model.
A 2025 study found that GHRP-2 decreased M1 macrophage polarization and improved histologic and biomechanical tendon-bone healing properties in a rat rotator cuff tear model. The peptide demonstrated increased bone mineral density, maximal failure load, and stiffness at the healing interface.
PreclinicalRobust growth hormone responses to GH-releasing peptide 2 in adolescents.
A 2024 retrospective study found that GHRP-2 elicited a robust growth hormone response in adolescents with idiopathic growth hormone deficiency and short stature. The findings demonstrated that current diagnostic cut-off levels for the GHRP-2 test may miss some patients and require revisiting.
Moderate§ Safety Profile
The most potent standard GHRP. Approved in Japan as a diagnostic tool (Pralmorelin). Raises cortisol and prolactin more than Ipamorelin but less than Hexarelin. Not FDA-approved for therapeutic use.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range100–300 mcg
Frequency1-3x daily
TimingPre-bed, morning fasted
Cycle Length8–16 weeks
BAC Water2 ml / 5mg vial
Most common dose: 150-300mcg per injection. Empty stomach required. Often considered the 'goldilocks' GHRP: stronger than Ipamorelin, fewer sides than GHRP-6.
§ Pharmacokinetics
⏱️ Half-Life: 1.5h
Plasma concentration over time§ Expected Outcomes
Week 1
Improved sleep quality; moderate appetite increase; GH flush sensation
Weeks 2–4
Enhanced recovery; early body composition shifts; IGF-1 elevation on bloodwork
Month 2–3
Significant lean mass improvement; fat redistribution; skin quality enhancement
Long-term
Sustained somatotropic axis support; cycling recommended every 12-16 weeks
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Moderate appetite increase Less intense than GHRP-6 but more than Ipamorelin | ~30% of users | mild |
Cortisol elevation (transient) | ~20% of users | mild |
Prolactin elevation (transient) Monitor if stacking with other prolactin-raising compounds | ~15% of users | mild |
Water retention | ~12% of users | mild |
Drowsiness / fatigue | ~8% of users | mild |
Where to Source GHRP-2 for Research
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⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
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