Hexarelin
Last reviewed May 27, 2026
Also known as: Examorelin, HEX
Quick Answer
Hexarelin is a ghrp research compound (not FDA-approved for human use) studied for most potent gh release of any ghrp. Hexarelin is the most potent growth-hormone-releasing peptide available, studied for producing the strongest GH pulses of any GHRP and for direct cardioprotective effects on heart tissue. Research dose: 100–200 mcg 1-2x daily. Half-life: 54 minutes. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mg1Amino Club Best $/mg
$44.79
$55.99Save $11.20
5mg vial
$11.20/mg
99%+ purityCOA · Apr 2026
Use code for 20% off:
Shop Amino Club Compare all 2 vendors →
Rankings independent · Research use only
Synthetic hexapeptide and the most potent GH secretagogue in the GHRP class. Acts on GHSR1a to produce the strongest acute GH pulse, but also significantly raises cortisol, prolactin, and ACTH. Notabl
Where to Buy Hexarelin
COA-verified vendors · Use code PEPTIDEX for up to 20% off
* Prices for research peptide acquisition. Not therapeutic products.
| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
| 99%+ | $55.995 mg | $44.79Save 20% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop | |
| 99%+ | $66.005 mg | $56.10Save 15% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop |
$55.99 · 5 mg$44.79−20%
Use code PEPTIDEX for 20% off at Amino Club.
* Research vendor — verify your regional regulations before purchase.
Shop at Amino Club$66.00 · 5 mg$56.10−15%
Use code PEPTIDEX for 15% off at Limitless Life.
* Research vendor — verify your regional regulations before purchase.
Shop at Limitless Life§ Mechanism of Action
Synthetic hexapeptide and the most potent GH secretagogue in the GHRP class. Acts on GHSR1a to produce the strongest acute GH pulse, but also significantly raises cortisol, prolactin, and ACTH. Notable for direct cardioprotective effects independent of GH release, binding to cardiac CD36 receptors to protect against ischemic damage. Develops tachyphylaxis (desensitization) faster than other GHRPs.
§ Primary Benefits
- 1Most potent GH release of any GHRP
- 2cardioprotection
- 3muscle growth
- 4recovery
§ Clinical Evidence
Hexarelin produces the strongest GH release among GHRPs
Ghigo et al. (J. Clin. Endocrinol. Metab.): Direct comparison study showing Hexarelin produces the highest peak GH response of any GHRP, significantly exceeding GHRP-6 and GHRP-2 in healthy subjects.
ModerateHexarelin cardioprotective effects via CD36 receptor
Bhatt et al.: Hexarelin binds cardiac CD36 scavenger receptors, providing direct cardioprotection independent of GH release. Reduces infarct size and improves cardiac function post-ischemia.
PreclinicalHexarelin improves cardiac function in GH-deficient adults
Bisi et al.: Chronic Hexarelin administration improves left ventricular ejection fraction and cardiac performance in GH-deficient adult patients.
ModerateHexarelin tachyphylaxis with chronic administration
Arvat et al.: Long-term Hexarelin use shows progressive GH response attenuation after 4-8 weeks of continuous dosing, necessitating cycling protocols for sustained efficacy.
Moderate§ Safety Profile
Most potent but least selective GHRP. Significant cortisol and prolactin elevation limits chronic use. Develops tachyphylaxis within 4-8 weeks requiring mandatory cycling. Cardioprotective properties make it uniquely valuable for cardiac research. Not FDA-approved.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range100–200 mcg
Frequency1-2x daily
TimingPre-bed or morning fasted
Cycle Length4–8 weeks
BAC Water2 ml / 5mg vial
Shorter cycles than other GHRPs (4-8 weeks max) due to tachyphylaxis. Standard dose: 100-200mcg. Often used in short 'burst' protocols for maximum GH output. Always cycle: 4 weeks on / 4 weeks off minimum.
§ Pharmacokinetics
⏱️ Half-Life: 54min
Plasma concentration over time§ Expected Outcomes
Week 1
Dramatic GH pulse; notable flush and warmth sensation; improved sleep depth
Weeks 2–4
Peak body composition effects; strongest anabolic window; IGF-1 significantly elevated
Month 2–3
Tachyphylaxis onset; GH response diminishes 40-60% by week 6-8; must cycle off
Long-term
Best used cyclically; cardiac benefits may persist beyond GH effects
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Cortisol elevation More significant than other GHRPs; monitor with chronic use | ~30% of users | moderate |
Prolactin elevation Can cause nipple sensitivity; necessitates cycling | ~25% of users | moderate |
Intense flushing / warmth | ~20% of users | mild |
Appetite increase | ~15% of users | mild |
Water retention | ~15% of users | mild |
Headache | ~8% of users | mild |
Where to Source Hexarelin for Research
Finding verified, high-purity Hexarelin requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified Hexarelin✓ Third-party tested·✓ US shipping·✓ COA on every batch
Disclosure: PeptiDex may earn a commission from purchases made through affiliate links. This does not affect our editorial independence or recommendations. We exclusively feature vendors that pass our strict quality verification protocols.
PEPTIDEX coupon for HexarelinSave 20% on Hexarelin at Amino Club & verified vendors →
Reconstitution CalculatorCalculate reconstitution for Hexarelin →
Compare ToolCompare Hexarelin to similar peptides →
§ Comparisons
Cite This Page
⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links on this page. This does not affect our editorial ranking or vendor recommendations — we exclusively feature vendors that pass independent COA verification. See our methodology · Editorial policy
Free Download
2026 Peptide Stack Cheat Sheet
12stacks • exact dosages • cycle lengths • printable reference
No spam. Unsubscribe anytime.
§ About the Author Verified
PeptiDex Research
Independent researcher, not a medical professional
PeptiDex Research is the byline used by the independent researcher who builds and maintains PeptiDex. The site is a one-person research project — there is no editorial board, no medical reviewers, and no clinical staff. Content is produced by reading...
View profileLast fact-checked: · PeptiDex Editorial Team