Also known as: EDR peptide, Glu-Asp-Arg
Pinealon is a khavinson peptide research compound (not FDA-approved for human use) studied for neuroprotection. Pinealon is a tiny tripeptide from Russian bioregulatory research that crosses into brain cells and modulates their gene expression, studied for neuroprotection and cognitive longevity. Research dose: 5–10 mg daily x 10 days. Half-life: not established. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Rankings independent · Research use only
Synthetic tripeptide (Glu-Asp-Arg) bioregulatory peptide developed by Khavinson's St. Petersburg Institute. Acts as a penetrating peptide that crosses the blood-brain barrier and enters neuronal cell
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
COA-verified vendors · Use code PEPTIDEX for up to 20% off
| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
Bio Longevity LabsTriple-Tested | 99%+ | $69.97/20mg | $59.47Save 15% | PEPTIDEX | Shop |
Use code PEPTIDEX for 15% off at Bio Longevity Labs.
Shop at Bio Longevity LabsAffiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links. This does not affect our editorial ranking. See our methodology. Prices shown are list prices at time of last update — verify on vendor site.
Pinealon (also known as EDR peptide, Glu-Asp-Arg) is a prominently researched experimental compound classified strictly within the Khavinson Peptide framework. Operating primarily through advanced pharmacological pathways, its core mechanism of action is as follows: it synthetic tripeptide (Glu-Asp-Arg) bioregulatory peptide developed by Khavinson's St. Petersburg Institute. Acts as a penetrating peptide that crosses the blood-brain barrier and enters neuronal cell nuclei. Modulates gene expression in brain tissue, upregulates antioxidant enzymes (catalase, superoxide dismutase), promotes neuroprotection, and supports the pineal gland's circadian regulation. Shown to reduce hypoxia-induced neuronal damage. with an established metabolic degradation profile, In preclinical investigative trials and independent academic studies, researchers utilizing Pinealon have documented significant, quantifiable biological outcomes, primarily focusing on neuroprotection, cognitive enhancement, antioxidant, circadian rhythm support. Typical research protocols investigate administering 5000 to 10000mcg via subq pathways daily x 10 days. However, it is critically important to understand that while Pinealon demonstrates profound physiological potential in highly controlled laboratory settings, it remains classified strictly as a research chemical and has not been approved by the United States Food and Drug Administration (FDA) for human therapeutic, diagnostic, or dietary consumption. Independent chemical analysis via rigorous third-party Certificate of Analysis (COA) testing utilizing High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) remains the industry gold standard for verifying its base elemental stability when reconstituted appropriately in sterile bacteriostatic water.
Synthetic tripeptide (Glu-Asp-Arg) bioregulatory peptide developed by Khavinson's St. Petersburg Institute. Acts as a penetrating peptide that crosses the blood-brain barrier and enters neuronal cell nuclei. Modulates gene expression in brain tissue, upregulates antioxidant enzymes (catalase, superoxide dismutase), promotes neuroprotection, and supports the pineal gland's circadian regulation. Shown to reduce hypoxia-induced neuronal damage.
Khavinson et al.: Pinealon treatment increased resistance of human neuroblastoma cells to hypoxia, upregulating catalase and superoxide dismutase expression and reducing oxidative damage.
PreclinicalKhavinson et al.: Review documenting the epigenetic mechanisms by which short Khavinson peptides including Pinealon modulate histone acetylation and gene expression in brain tissue to slow aging.
PreclinicalBased on Russian bioregulatory research. Limited Western RCT validation. Generally considered safe in published use. Not FDA-approved. Research only. Caution: Khavinson research base has limited independent Western reproducibility.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.
Khavinson protocol: 5–10mg per course. Intranasal administration also studied. No validated Western dosing.
Week 1
Neuroprotection markers in preclinical models
Month 2–3
Cognitive and circadian rhythm support in published cohort studies
| Side Effect | Incidence | Severity |
|---|---|---|
Injection site reaction | Rare | mild |
Finding verified, high-purity Pinealon requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified Pinealon✓ Third-party tested·✓ US shipping·✓ COA on every batch
Disclosure: PeptiDex may earn a commission from purchases made through affiliate links. This does not affect our editorial independence or recommendations. We exclusively feature vendors that pass our strict quality verification protocols.
⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links on this page. This does not affect our editorial ranking or vendor recommendations — we exclusively feature vendors that pass independent COA verification. See our methodology · Editorial policy
12 stacks • exact dosages • cycle lengths • printable reference
No spam. Unsubscribe anytime.
Independent researcher, not a medical professional
PeptiDex Research is the byline used by the independent researcher who builds and maintains PeptiDex. The site is a one-person research project — there is no editorial board, no medical reviewers, and no clinical staff. Content is produced by reading...
View profile