PeptiDex
Peptide Research Index
Research-backed
Peptide Research Index
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
Natural GH pulse stimulation. Mimics endogenous GHRH to stimulate the pituitary gland's own growth hormone production in a physiologic, pulsatile pattern.
Vittone et al.: Sermorelin treatment significantly increases lean body mass, improves body composition, and enhances GH/IGF-1 levels in older adults.
moderate strongPrakash & Garg: FDA-approved indication sermorelin produces significant and sustained height velocity increases in prepubertal children with GH deficiency.
strongVeldhuis et al. (J. Clin. Endocrinol. Metab.): Demonstrates sermorelin injections effectively restore GH and IGF-1 levels in older men with age-related GH decline.
moderate strongStudy examining sermorelin's ability to stimulate GH/IGF-1 secretion in men and women, identifying gender-specific anabolic benefits and dosing considerations.
moderateVery safe; mimics physiology. Previously FDA-approved for GH deficiency diagnosis. Well-tolerated.
⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.
Inject before bed for maximum GH pulse during sleep. Very short half-life = frequent dosing.
Last updated: 2026-01 · Laws change frequently. Verify current status in your jurisdiction.
Week 1
Improved sleep depth; GH pulse enhancement during sleep
Weeks 2-4
Increased energy and recovery; some users report improved skin quality
Month 2-3
Body composition improvements; IGF-1 elevation on bloodwork
Long-term
Sustained GH axis support with physiologic (non-suppressive) mechanism
| Side Effect | Incidence | Severity |
|---|---|---|
Injection site reactions | ~8% of users | mild |
Headache | ~5% of users | mild |
Flushing | ~6% of users | mild |
Dizziness | ~3% of users | mild |
Incidence rates sourced from published clinical trial data where available; otherwise based on community research observations.
Maximize lean muscle gain through GH optimization, growth factor signaling, and myostatin inhibition
Support healthy testosterone levels and hormonal balance while preserving fertility
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