Also known as: Intranasal Synapsin, RG3 + NAD+ compound
Synapsin is a nootropic peptide research compound (not FDA-approved for human use) studied for cognitive enhancement. Synapsin is a compounded intranasal cognitive blend (Rg3 + NAD+) used by functional medicine practitioners for brain fog, TBI recovery, and cognitive enhancement. It's a compound formulation, not a single peptide. Research dose: 100–200 mcg daily. Half-life: not established. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Sourcing data for Synapsin is updating.
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Sourcing data for Synapsin is updating.
We verify new listings weekly — check back soon.
Compounded intranasal formulation (not a single peptide) combining Rg3 (ginsenoside), NAD+, and additional neuroprotective compounds. Rg3 modulates NMDA and GABA receptor activity, reduces neuroinflam
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
COA-verified vendors · Use code PEPTIDEX for up to 20% off
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Compare All VendorsSynapsin (also known as Intranasal Synapsin, RG3 + NAD+ compound) is a prominently researched experimental compound classified strictly within the Nootropic Peptide framework. Operating primarily through advanced pharmacological pathways, its core mechanism of action is as follows: it compounded intranasal formulation (not a single peptide) combining Rg3 (ginsenoside), NAD+, and additional neuroprotective compounds. Rg3 modulates NMDA and GABA receptor activity, reduces neuroinflammation via NF-kB inhibition, and promotes BDNF expression. NAD+ component supports mitochondrial function and sirtuin activation. Intranasal delivery bypasses blood-brain barrier. Often used in TBI, post-COVID cognitive impairment, and neurodegenerative disease support protocols. with an established metabolic degradation profile, In preclinical investigative trials and independent academic studies, researchers utilizing Synapsin have documented significant, quantifiable biological outcomes, primarily focusing on cognitive enhancement, neuroprotection, mitochondrial function, synaptic plasticity. Typical research protocols investigate administering 100 to 200mcg via nasal pathways daily. However, it is critically important to understand that while Synapsin demonstrates profound physiological potential in highly controlled laboratory settings, it remains classified strictly as a research chemical and has not been approved by the United States Food and Drug Administration (FDA) for human therapeutic, diagnostic, or dietary consumption. Independent chemical analysis via rigorous third-party Certificate of Analysis (COA) testing utilizing High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) remains the industry gold standard for verifying its base elemental stability when reconstituted appropriately in sterile bacteriostatic water.
Compounded intranasal formulation (not a single peptide) combining Rg3 (ginsenoside), NAD+, and additional neuroprotective compounds. Rg3 modulates NMDA and GABA receptor activity, reduces neuroinflammation via NF-kB inhibition, and promotes BDNF expression. NAD+ component supports mitochondrial function and sirtuin activation. Intranasal delivery bypasses blood-brain barrier. Often used in TBI, post-COVID cognitive impairment, and neurodegenerative disease support protocols.
Research only. Compounded intranasal formulation — individual components (Rg3, NAD+) have some published safety data but the specific compound blend lacks clinical trial validation. Not FDA-approved. Used in functional medicine under practitioner supervision.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.
Compounded intranasal formulation; dosing varies by compounding pharmacy formulation. Rg3 typically 0.5–1mg per dose. Research use only.
Week 1
Acute cognitive effects reported; improved focus and mental clarity
Weeks 2–4
Neuroinflammation reduction in clinical observations
| Side Effect | Incidence | Severity |
|---|---|---|
Nasal irritation | ~10% | mild |
Mild headache | ~5% | mild |
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⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
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