Tesofensine
Last reviewed May 27, 2026
Also known as: NS2330
Quick Answer
Tesofensine is a small molecule research compound (not FDA-approved for human use) studied for extreme fat loss and appetite suppression without glp-1 side effects. Tesofensine is an investigational triple monoamine reuptake inhibitor originally developed for Alzheimer's disease, studied for powerful appetite suppression and weight loss exceeding 10% in 24 weeks. Research dose: 250–500 mcg daily. Half-life: 9 days. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mgSourcing data for Tesofensine is updating.
We verify new listings weekly — check back soon.
Where to Source
Ranked by $/mgSourcing data for Tesofensine is updating.
We verify new listings weekly — check back soon.
Triple monoamine reuptake inhibitor (inhibits reuptake of serotonin, noradrenaline, and dopamine). Originates as an Alzheimer's/Parkinson's drug but abandoned due to massive weight loss profiles.
Where to Buy Tesofensine
COA-verified vendors · Use code PEPTIDEX for up to 20% off
Verified pricing for Tesofensine is not yet available in our database. Browse all COA-verified vendors on our price comparison tool, or check individual vendor pages.
Compare All Vendors§ Mechanism of Action
Triple monoamine reuptake inhibitor (inhibits reuptake of serotonin, noradrenaline, and dopamine). Originates as an Alzheimer's/Parkinson's drug but abandoned due to massive weight loss profiles.
§ Primary Benefits
- 1Extreme fat loss and appetite suppression without GLP-1 side effects
§ Clinical Evidence
Tesofensine induces profound weight loss
Phase 2 Lancet study showing 12.8 kg (10.6%) weight loss over 24 weeks at 1mg dose.
StrongTesofensine--a novel potent weight loss medicine. Evaluation of: Astrup A, Breum L, Jensen TJ, Kroustrup JP, Larsen TM. Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial. Lancet 2008;372:1906-13.
A study published in Expert opinion on investigational drugs investigating the effects and mechanisms.
ModerateWeight loss produced by tesofensine in patients with Parkinson's or Alzheimer's disease.
A study published in Obesity (Silver Spring, Md.) investigating the effects and mechanisms.
ModerateTesofensine and weight loss.
A study published in Lancet (London, England) investigating the effects and mechanisms.
PreclinicalA quantitative enterohepatic circulation model: development and evaluation with tesofensine and meloxicam.
A study published in Clinical pharmacokinetics investigating the effects and mechanisms.
PreclinicalExpression of concern--effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial.
A study published in Lancet (London, England) investigating the effects and mechanisms.
ModerateTesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons.
A study published in PloS one investigating the effects and mechanisms.
PreclinicalEffect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial.
A study published in Lancet (London, England) investigating the effects and mechanisms.
ModerateNew and emerging drug molecules against obesity.
A study published in Journal of cardiovascular pharmacology and therapeutics investigating the effects and mechanisms.
PreclinicalQuantitative pharmacology approach in Alzheimer's disease: efficacy modeling of early clinical data to predict clinical outcome of tesofensine.
A study published in The AAPS journal investigating the effects and mechanisms.
Moderate§ Safety Profile
Research-only. Potent CNS stimulant. Can cause insomnia, elevated heart rate, and dry mouth. Half-life is extremely long, leading to accumulation in the system.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteOral
Dose Range250–500 mcg
FrequencyDaily
TimingEarly Morning
Cycle Length12–24 weeks
0Do not exceed 0.5mg/day due to heart rate spikes. Taken via capsule, not injected.
§ Pharmacokinetics
⏱️ Half-Life: 9d
Plasma concentration over time§ Expected Outcomes
Week 1
Complete abolition of hunger cravings, massive energy
Month 2–3
10%+ body weight loss
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Insomnia | ~15% of users | moderate |
Dry Mouth | ~20% of users | mild |
Elevated Heart Rate | ~12% of users | moderate |
Where to Source Tesofensine for Research
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§ Comparisons
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⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
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