Peptide Research Index
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
Also: NS2330
Small MoleculeLast Updated: April 1, 2026
Tesofensine (also known as NS2330) is a prominently researched experimental compound classified strictly within the Small Molecule framework. Operating primarily through advanced pharmacological pathways, it functions by triple monoamine reuptake inhibitor (inhibits reuptake of serotonin, noradrenaline, and dopamine). Originates as an Alzheimer's/Parkinson's drug but abandoned due to massive weight loss profiles. with a documented biological half-life of roughly 216 hours, in preclinical investigative trials and independent academic studies, researchers utilizing Tesofensine have documented significant, quantifiable biological outcomes, primarily focusing on extreme fat loss and appetite suppression without glp-1 side effects. Typical research protocols investigate administering 250 to 500mcg via oral pathways daily. However, it is critically important to understand that while Tesofensine demonstrates profound physiological potential in highly controlled laboratory settings, it remains classified strictly as a research chemical and has not been approved by the United States Food and Drug Administration (FDA) for human therapeutic, diagnostic, or dietary consumption. Independent chemical analysis via rigorous third-party Certificate of Analysis (COA) testing utilizing High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) remains the industry gold standard for verifying its base elemental stability when reconstituted appropriately in sterile bacteriostatic water.
Triple monoamine reuptake inhibitor (inhibits reuptake of serotonin, noradrenaline, and dopamine). Originates as an Alzheimer's/Parkinson's drug but abandoned due to massive weight loss profiles.
Research-only. Potent CNS stimulant. Can cause insomnia, elevated heart rate, and dry mouth. Half-life is extremely long, leading to accumulation in the system.
⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.
Do not exceed 0.5mg/day due to heart rate spikes. Taken via capsule, not injected.
Week 1
Complete abolition of hunger cravings, massive energy
Month 2-3
10%+ body weight loss
| Side Effect | Incidence | Severity |
|---|---|---|
Insomnia | ~15% of users | moderate |
Dry Mouth | ~20% of users | mild |
Elevated Heart Rate | ~12% of users | moderate |
Incidence rates sourced from published clinical trial data where available; otherwise based on community research observations.
Finding verified, high-purity Tesofensine requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified Tesofensine✓ Third-party tested·✓ US shipping·✓ COA on every batch
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PeptiDex. (2026). Tesofensine. PeptiDex Research Platform. https://peptidex.app/library/tesofensine
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