Overview
KPV is classified as a anti-inflammatory peptide. Gut/injury healing, inflammation reduction.
Alpha-MSH fragment that potently suppresses NF-κB inflammatory signaling. Reduces pro-inflammatory cytokines and promotes mucosal healing.
Also known as: Lys-Pro-Val
Category
Anti-Inflammatory
Half-Life
0.5h
Route
SubQ
FDA Status
Not Approved
How Does KPV Work?
Alpha-MSH fragment that potently suppresses NF-κB inflammatory signaling. Reduces pro-inflammatory cytokines and promotes mucosal healing.
At the molecular level, KPV operates through pathways characteristic of the Anti-Inflammatory class, interacting with target receptors and downstream signaling cascades to produce its observed effects.
Published Research
The following studies are indexed from PubMed and peer-reviewed journals:
[1]KPV anti-inflammatory effects in murine colitis
Dalmasso et al. (PLoS One): KPV demonstrates significant anti-inflammatory effects in murine models of inflammatory bowel disease, suppressing NF-κB and MAPK pathways.
Evidence: preclinical[2]KPV suppresses NF-κB signaling in airway epithelium
Study shows KPV inhibits p65RelA nuclear import, suppressing NF-κB inflammatory signaling in airway epithelial cells — relevant to respiratory and gut inflammation.
Evidence: preclinical[3]KPV-loaded nanoparticles for oral IBD treatment
Hyaluronic acid-functionalized nanoparticle delivery of KPV enhances oral bioavailability and anti-inflammatory efficacy in colitis models, supporting clinical translation.
Evidence: preclinical[4]KPV reduces pro-inflammatory cytokines (IL-1β, IL-6, TNF-α)
KPV selectively suppresses production of IL-1β, IL-6, IL-12, TNF-α, and IFN-γ in colonic epithelial and immune cells, with effects mediated via intracellular PepT1 transport.
Evidence: preclinicalSafety Profile
Excellent profile. Research-only compound with limited human data but strong preclinical safety.
| Side Effect | Incidence | Severity |
|---|---|---|
| Generally very well-tolerated | Very limited human data | mild |
| Mild GI adjustment | ~5% of users (oral route) | mild |
Sourcing KPV for Research
If you're looking to source KPV for laboratory research, our vendor directory compares pricing, purity testing, and COA verification from independently vetted suppliers.
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Full Research Profile
KPV — dosing, interactions, timelines & more
Comprehensive compound profile with sourcing information, stacking synergies, and outcome timelines.