PeptiDex
Peptide Research Index
Research-backed
Peptide Research Index
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
Also: Lys-Pro-Val
🩹Anti-InflammatoryAlpha-MSH fragment that potently suppresses NF-κB inflammatory signaling. Reduces pro-inflammatory cytokines and promotes mucosal healing.
Dalmasso et al. (PLoS One): KPV demonstrates significant anti-inflammatory effects in murine models of inflammatory bowel disease, suppressing NF-κB and MAPK pathways.
preclinicalStudy shows KPV inhibits p65RelA nuclear import, suppressing NF-κB inflammatory signaling in airway epithelial cells — relevant to respiratory and gut inflammation.
preclinicalHyaluronic acid-functionalized nanoparticle delivery of KPV enhances oral bioavailability and anti-inflammatory efficacy in colitis models, supporting clinical translation.
preclinicalKPV selectively suppresses production of IL-1β, IL-6, IL-12, TNF-α, and IFN-γ in colonic epithelial and immune cells, with effects mediated via intracellular PepT1 transport.
preclinicalExcellent profile. Research-only compound with limited human data but strong preclinical safety.
⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.
Often used orally in capsules for gut-specific effects. SubQ for systemic anti-inflammatory.
Last updated: 2026-01 · Laws change frequently. Verify current status in your jurisdiction.
Week 1
Potent anti-inflammatory effect; rapid symptom relief in gut/injury
Weeks 2-4
Mucosal healing acceleration; reduced IBD flare symptoms
Month 2-3
Wound healing and IBD remission in study models; sustained anti-inflammatory effect
| Side Effect | Incidence | Severity |
|---|---|---|
Generally very well-tolerated | Very limited human data | mild |
Mild GI adjustment | ~5% of users (oral route) | mild |
Incidence rates sourced from published clinical trial data where available; otherwise based on community research observations.
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