Overview
Selank is classified as a anxiolytic peptide peptide. Anxiety reduction, mental clarity, mood.
Modulates GABA/serotonin neurotransmitter systems. Enhances immune function by influencing IL-6 and T-helper cell balance. Stabilizes enkephalin levels.
Also known as: TP-7
Category
Anxiolytic Peptide
Half-Life
0.5h
Route
Nasal
FDA Status
Not Approved
How Does Selank Work?
Modulates GABA/serotonin neurotransmitter systems. Enhances immune function by influencing IL-6 and T-helper cell balance. Stabilizes enkephalin levels.
At the molecular level, Selank operates through pathways characteristic of the Anxiolytic Peptide class, interacting with target receptors and downstream signaling cascades to produce its observed effects.
Published Research
The following studies are indexed from PubMed and peer-reviewed journals:
[1]Selank anxiolytic effects in humans
Clinical trial demonstrates Selank's anxiolytic efficacy in patients with generalized anxiety disorder, comparable to benzodiazepines but without sedation or dependence.
Evidence: moderate[2]Selank anti-anxiety effects comparable to benzodiazepines
Study confirms Selank provides significant anti-anxiety effects comparable to benzodiazepine treatment, with added cognitive enhancement and no addictive potential.
Evidence: moderate[3]Selank increases BDNF in hippocampus and prefrontal cortex
Selank increases BDNF production in the rat hippocampus and prefrontal cortex, preventing ethanol-induced memory impairment and enhancing synaptic plasticity.
Evidence: preclinical[4]Selank modulates GABA receptor gene expression
Molecular study showing Selank influences GABA-A receptor subunit gene expression, providing mechanism for its anxiolytic effects without sedation.
Evidence: preclinical[5]GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells.
A study published in Frontiers in pharmacology investigating the effects and mechanisms.
Evidence: preclinical[6]Functional Connectomic Approach to Studying Selank and Semax Effects.
A study published in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections investigating the effects and mechanisms.
Evidence: preclinical[7]Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.
A study published in Protein and peptide letters investigating the effects and mechanisms.
Evidence: preclinical[8][Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].
A study published in Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova investigating the effects and mechanisms.
Evidence: preclinical[9]Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.
A study published in Frontiers in pharmacology investigating the effects and mechanisms.
Evidence: preclinical[10]The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action.
A study published in Molecular immunology investigating the effects and mechanisms.
Evidence: preclinical[11]The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress.
A study published in Current reviews in clinical and experimental pharmacology investigating the effects and mechanisms.
Evidence: preclinical[12][Comparison of anticoagulant effects of regulatory proline-containing oligopeptides. Specificity of glyprolines, semax, and selank and potential of their practical application].
A study published in Izvestiia Akademii nauk. Seriia biologicheskaia investigating the effects and mechanisms.
Evidence: preclinical[13][Optimization of the treatment of anxiety disorders with selank].
A study published in Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova investigating the effects and mechanisms.
Evidence: preclinical[14][Effects of the new peptide anxiolytic drug selank on the cardiovascular system functioning and respiration in cats].
A study published in Eksperimental'naia i klinicheskaia farmakologiia investigating the effects and mechanisms.
Evidence: preclinical[15]Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats.
A study published in Behavioural neurology investigating the effects and mechanisms.
Evidence: preclinical[16][COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.].
A study published in Eksperimental'naia i klinicheskaia farmakologiia investigating the effects and mechanisms.
Evidence: preclinical[17]Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress.
A study published in Bulletin of experimental biology and medicine investigating the effects and mechanisms.
Evidence: preclinical[18]State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment.
A study published in Bulletin of experimental biology and medicine investigating the effects and mechanisms.
Evidence: preclinical[19]Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank.
A study published in Regulatory peptides investigating the effects and mechanisms.
Evidence: preclinical[20]Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank.
A study published in Bulletin of experimental biology and medicine investigating the effects and mechanisms.
Evidence: preclinicalSafety Profile
Very safe profile. No reported dependence or withdrawal. Approved as anxiolytic in Russia. Not FDA-approved in US.
| Side Effect | Incidence | Severity |
|---|---|---|
| Mild fatigue | ~5% of users | mild |
| Nasal irritation | ~6% of users | mild |
| Mood fluctuation | ~3% of users | mild |
Sourcing Selank for Research
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* Research vendor — verify your regional regulations before purchase.
Full Research Profile
Selank — dosing, interactions, timelines & more
Comprehensive compound profile with sourcing information, stacking synergies, and outcome timelines.