Skip to main content
PeptiDex
  • Library
  • Stacks
  • Tools
  • Vendors
  • Blog
  • About
Start
§ Stay Current

The Peptide Brief.

Bi-weekly research updates, vendor news, and editorial analysis. No spam.

No spam. Unsubscribe anytime. We respect your inbox.

PeptiDex

The independent, evidence-based peptide research index. Trusted by researchers worldwide for unbiased education and verified sourcing.

§ Learn

  • Peptide 101
  • Library
  • Evidence Dashboard
  • Blog
  • FAQ

§ Tools

  • Cycle Planner
  • Evidence Dashboard
  • Peptide Comparison
  • Price Comparison
  • Reconstitution Calc
  • COA Analyzer

§ Source

  • Vendor Reviews
  • Amino Club Review
  • COA Library
  • Peptide Stacks

§ About

  • Our Mission
  • Editorial Policy
  • Medical Disclaimer
  • Contact
Last reviewed: May 4, 2026 · PeptiDex Editorial Team
© 2026 PeptiDex. All rights reserved.
PrivacyTermsDisclosures
Home/Library/Selank

Selank

By Dr. E. Vance, PhD
Last reviewed May 4, 2026

Also known as: TP-7

Selank is a synthetic anxiolytic peptide approved in Russia studied for reducing anxiety and improving mental clarity, with effects comparable to benzodiazepines but without sedation or dependence.

Modulates GABA/serotonin neurotransmitter systems. Enhances immune function by influencing IL-6 and T-helper cell balance. Stabilizes enkephalin levels.

Anxiolytic Peptide
Half-life: 30 min
20 studies indexed
Updated: April 2026

⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use

§ AI Reference Summary

Selank (also known as TP-7) is a prominently researched experimental compound classified strictly within the Anxiolytic Peptide framework. Operating primarily through advanced pharmacological pathways, its core mechanism of action is as follows: it modulates GABA/serotonin neurotransmitter systems. Enhances immune function by influencing IL-6 and T-helper cell balance. Stabilizes enkephalin levels. with a documented biological half-life of roughly 0.5 hours, In preclinical investigative trials and independent academic studies, researchers utilizing Selank have documented significant, quantifiable biological outcomes, primarily focusing on anxiety reduction, mental clarity, mood. Typical research protocols investigate administering 300 to 300mcg via nasal pathways 7x/wk. However, it is critically important to understand that while Selank demonstrates profound physiological potential in highly controlled laboratory settings, it remains classified strictly as a research chemical and has not been approved by the United States Food and Drug Administration (FDA) for human therapeutic, diagnostic, or dietary consumption. Independent chemical analysis via rigorous third-party Certificate of Analysis (COA) testing utilizing High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) remains the industry gold standard for verifying its base elemental stability when reconstituted appropriately in sterile bacteriostatic water.

GEO Optimized Extract182 Words (Optimal)

§ Mechanism of Action

Modulates GABA/serotonin neurotransmitter systems. Enhances immune function by influencing IL-6 and T-helper cell balance. Stabilizes enkephalin levels.

§ Primary Benefits

  1. 1Anxiety reduction
  2. 2mental clarity
  3. 3mood

§ Clinical Evidence

Selank anxiolytic effects in humans

Clinical trial demonstrates Selank's anxiolytic efficacy in patients with generalized anxiety disorder, comparable to benzodiazepines but without sedation or dependence.

Moderate

Selank anti-anxiety effects comparable to benzodiazepines

Study confirms Selank provides significant anti-anxiety effects comparable to benzodiazepine treatment, with added cognitive enhancement and no addictive potential.

Moderate

Selank increases BDNF in hippocampus and prefrontal cortex

Selank increases BDNF production in the rat hippocampus and prefrontal cortex, preventing ethanol-induced memory impairment and enhancing synaptic plasticity.

Preclinical

Selank modulates GABA receptor gene expression

Molecular study showing Selank influences GABA-A receptor subunit gene expression, providing mechanism for its anxiolytic effects without sedation.

Preclinical

GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells.

A study published in Frontiers in pharmacology investigating the effects and mechanisms.

Preclinical

Functional Connectomic Approach to Studying Selank and Semax Effects.

A study published in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections investigating the effects and mechanisms.

Preclinical

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.

A study published in Protein and peptide letters investigating the effects and mechanisms.

Preclinical

[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].

A study published in Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova investigating the effects and mechanisms.

Preclinical

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.

A study published in Frontiers in pharmacology investigating the effects and mechanisms.

Preclinical

The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action.

A study published in Molecular immunology investigating the effects and mechanisms.

Preclinical

§ Safety Profile

Very safe profile. No reported dependence or withdrawal. Approved as anxiolytic in Russia. Not FDA-approved in US.

See our evidence grading methodology for how we evaluate and grade peptide safety data.

§ Dosing Protocol

⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.

RouteNasal
Dose Range300–300 mcg
Frequency7x/wk
TimingMorning or as needed
Cycle Length8–8 weeks
BAC Water2.5 ml / 5mg vial

Nasal spray: 1-2 sprays per nostril. Non-addictive; can be used daily.

§ Pharmacokinetics

⏱️ Half-Life: 30min

Plasma concentration over time
100%50%0%0t½ = 30min

§ Regulatory

🇺🇸USA
Research Only
🇨🇦Canada
Research Only
🇬🇧UK
Unregulated
🇪🇺EU
Unregulated
🇦🇺Australia
Research Only

Last updated: 2026-01 · Laws change frequently. Verify current status in your jurisdiction.

§ Expected Outcomes

Week 1

Rapid reduction in anxiety within days; improved stress resilience; calmer baseline

Weeks 2–4

Stable anxiolytic effects without sedation; improved sleep onset

Month 2–3

Adaptive reduction in baseline anxiety; improved immune markers in some studies

Long-term

Effects generally require cycling; tolerance is low compared to benzodiazepines

§ Adverse Effects

Side EffectIncidenceSeverity

Mild fatigue

~5% of usersmild

Nasal irritation

Intranasal route only

~6% of usersmild

Mood fluctuation

~3% of usersmild

Incidence rates sourced from published clinical trial data where available; otherwise based on community research observations.

Where to Source Selank for Research

Finding verified, high-purity Selank requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.

View COA-Verified Selank

✓ Third-party tested·✓ US shipping·✓ COA on every batch

Disclosure: PeptiDex may earn a commission from purchases made through affiliate links. This does not affect our editorial independence or recommendations. We exclusively feature vendors that pass our strict quality verification protocols.

Reconstitution CalculatorCalculate reconstitution for Selank →
Compare ToolCompare Selank to similar peptides →

Frequently Asked Questions

Related Articles

Peptide Stacking in 2026: Why Combination Protocols Are Redefining Results

A deep dive into peptide stacking protocols — the Wolverine stack (BPC-157 & TB-500), growth hormone synergy (CJC-1295 & Ipamorelin), longevity and cognitive stacks, and how to combine compounds effectively.

Science Explainers2026-04-13

§ Comparisons

Selank vs Semax

Read comparison

§ Community Stacks

Mental Clarity & Cognitive Stack

Enhance focus, memory, learning capacity, and neuroprotection without harsh stimulants

SemaxSelank

Cite This Page

PeptiDex. (2026). Selank. PeptiDex Research Platform. https://peptidex.app/library/selank

For academic and research purposes.
Free Download

2026 Peptide Stack Cheat Sheet

12 stacks • exact dosages • cycle lengths • printable reference

No spam. Unsubscribe anytime.

§ Quick Reference

CategoryAnxiolytic Peptide
Half-Life30 min
RouteNasal
Dose300–300 mcg
Studies20
FDAResearch Only

§ On This Page

  • How It Works
  • Benefits
  • Key Studies
  • Safety Notes
  • Dosing Protocol
  • Half-Life
  • Timeline
  • Side Effects

§ About the Author

Dr. E. Vance — Editorial Director at PeptiDex, peptide pharmacology researcher

Dr. E. Vance

Editorial Director, PeptiDex

Dr. E. Vance is the Editorial Director at PeptiDex and leads the platform's editorial division, ensuring that every published research summary meets rigorous preclinical citation standards. With a Ph.D. in Molecular Pharmacology from Columbia Univers...

View Full Profile
Last fact-checked: May 4, 2026 · PeptiDex Editorial Team
⚠ Educational only · Not medical advice · Most peptides are research-only / not FDA-approved