Overview
Synapsin is classified as a nootropic peptide peptide. Cognitive enhancement, neuroprotection, mitochondrial function, synaptic plasticity.
Compounded intranasal formulation (not a single peptide) combining Rg3 (ginsenoside), NAD+, and additional neuroprotective compounds. Rg3 modulates NMDA and GABA receptor activity, reduces neuroinflammation via NF-kB inhibition, and promotes BDNF expression. NAD+ component supports mitochondrial function and sirtuin activation. Intranasal delivery bypasses blood-brain barrier. Often used in TBI, post-COVID cognitive impairment, and neurodegenerative disease support protocols.
Also known as: Intranasal Synapsin, RG3 + NAD+ compound
Category
Nootropic Peptide
Route
Nasal
FDA Status
Not Approved
How Does Synapsin Work?
Compounded intranasal formulation (not a single peptide) combining Rg3 (ginsenoside), NAD+, and additional neuroprotective compounds. Rg3 modulates NMDA and GABA receptor activity, reduces neuroinflammation via NF-kB inhibition, and promotes BDNF expression. NAD+ component supports mitochondrial function and sirtuin activation. Intranasal delivery bypasses blood-brain barrier. Often used in TBI, post-COVID cognitive impairment, and neurodegenerative disease support protocols.
At the molecular level, Synapsin operates through pathways characteristic of the Nootropic Peptide class, interacting with target receptors and downstream signaling cascades to produce its observed effects.
Published Research
The following studies are indexed from PubMed and peer-reviewed journals:
Safety Profile
Research only. Compounded intranasal formulation — individual components (Rg3, NAD+) have some published safety data but the specific compound blend lacks clinical trial validation. Not FDA-approved. Used in functional medicine under practitioner supervision.
| Side Effect | Incidence | Severity |
|---|---|---|
| Nasal irritation | ~10% | mild |
| Mild headache | ~5% | mild |
Sourcing Synapsin for Research
If you're looking to source Synapsin for laboratory research, our vendor directory compares pricing, purity testing, and COA verification from independently vetted suppliers.
* Research vendor — verify your regional regulations before purchase.
Full Research Profile
Synapsin — dosing, interactions, timelines & more
Comprehensive compound profile with sourcing information, stacking synergies, and outcome timelines.