PeptiDex is an independent research reference. We are not a pharmacy, clinic, or medical provider. We do not sell, ship, or handle controlled substances. We provide educational reference material for researchers studying peptide pharmacology. All efficacy claims attributed to published peer-reviewed sources.
"The Mitochondrial Duo"
Cellular energy optimization, exercise performance, metabolic health, anti-aging
MOTS-c activates AMPK for metabolic optimization from the outside in, while SS-31 (Elamipretide) stabilizes the inner mitochondrial membrane from within. Together they attack mitochondrial decline from both directions.
MOTS-c is a mitochondrial-derived peptide that activates AMPK and enhances glucose uptake. SS-31 targets cardiolipin in the inner mitochondrial membrane to stabilize cristae and optimize electron transport chain efficiency.
Typical Ratio: MOTS-c 5-10mg + SS-31 5-10mg per dose
MOTS-c 5-10mg SubQ 3-5x/week (morning/pre-exercise). SS-31 5-10mg SubQ daily. Cycle 4-12 weeks.
Week 1
Improved insulin sensitivity; reduced exercise fatigue
Weeks 2–4
Enhanced exercise capacity; improved endurance and recovery
Months 2–3
Metabolic optimization; improved body composition; better VO2
Long-term
Sustained mitochondrial protection; cellular energy optimization
Both well-tolerated. SS-31 has been through multiple Phase 2/3 trials. MOTS-c has limited human data but is endogenous.
Research use only. Not FDA-approved for the combination described. Consult a qualified healthcare provider before use.