PeptiDex
Peptide Research Index
Research-backed
Peptide Research Index
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
Also: Mitochondrial ORF of 12S rRNA Type-c
âš¡Mitochondrial PeptideRegulates mitochondrial function and AMPK. Enhances glucose uptake and fatty acid oxidation, improves insulin sensitivity, and protects against age-related metabolic decline.
Lee et al. (Cell Metabolism): Discovery paper showing MOTS-c is a mitochondrial-derived peptide that regulates insulin sensitivity and metabolic homeostasis via AMPK activation.
emergingLee et al.: MOTS-c treatment prevents both age-dependent and high-fat-diet-induced insulin resistance and diet-induced obesity in mouse models.
preclinicalStudy demonstrating MOTS-c specifically targets skeletal muscle glucose metabolism, providing molecular basis for metabolic benefits and exercise-mimetic properties.
preclinicalHuman observational study linking decreased circulating MOTS-c levels with aging, obesity, and type 2 diabetes suggesting therapeutic rationale for supplementation.
emergingPromising but limited human data. As an endogenous peptide, theoretical biocompatibility favorable.
⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.
Exercise-mimetic. Often taken pre-workout. Higher doses used in research.
Last updated: 2026-01 · Laws change frequently. Verify current status in your jurisdiction.
Week 1
Improved insulin sensitivity; increased energy during exercise
Weeks 2-4
Enhanced exercise performance and endurance; reduced muscle fatigue
Month 2-3
Metabolic adaptations; improved body composition
Long-term
Mitochondrial health optimization; age-related metabolic protection
| Side Effect | Incidence | Severity |
|---|---|---|
Injection site reaction | ~5% of users | mild |
Generally well-tolerated | Very limited human data | mild |
Incidence rates sourced from published clinical trial data where available; otherwise based on community research observations.
Maximum fat loss through multi-pathway metabolic optimization
Improve metabolic health, insulin sensitivity, and cellular energy production
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