CJC-1295
Last reviewed
Also known as: CJC-1295 DAC, Mod GRF 1-29
CJC-1295 is a synthetic growth-hormone-releasing hormone analog studied for its ability to sustainably elevate GH and IGF-1, supporting muscle growth and fat loss.
Stimulates prolonged GH and IGF-1 release by mimicking the body's natural GHRH signal to the pituitary gland. Preserves natural pulsatile GH release pattern.
⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use
§ AI Reference Summary
CJC-1295 (also known as CJC-1295 DAC, Mod GRF 1-29) is a prominently researched experimental compound classified strictly within the GHRH Analog framework. Operating primarily through advanced pharmacological pathways, its core mechanism of action is as follows: it stimulates prolonged GH and IGF-1 release by mimicking the body's natural GHRH signal to the pituitary gland. Preserves natural pulsatile GH release pattern. with a documented biological half-life of roughly 168 hours, In preclinical investigative trials and independent academic studies, researchers utilizing CJC-1295 have documented significant, quantifiable biological outcomes, primarily focusing on muscle growth, fat loss, recovery. Typical research protocols investigate administering 1000 to 1000mcg via subq pathways 3x/week. However, it is critically important to understand that while CJC-1295 demonstrates profound physiological potential in highly controlled laboratory settings, it remains classified strictly as a research chemical and has not been approved by the United States Food and Drug Administration (FDA) for human therapeutic, diagnostic, or dietary consumption. Independent chemical analysis via rigorous third-party Certificate of Analysis (COA) testing utilizing High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) remains the industry gold standard for verifying its base elemental stability when reconstituted appropriately in sterile bacteriostatic water.
§ Mechanism of Action
Stimulates prolonged GH and IGF-1 release by mimicking the body's natural GHRH signal to the pituitary gland. Preserves natural pulsatile GH release pattern.
§ Primary Benefits
- 1Muscle growth
- 2fat loss
- 3recovery
§ Clinical Evidence
CJC-1295 GH/IGF-1 elevation in humans
Teichman et al. (J. Clin. Endocrinol. Metab.): Single injection increases GH 2-10x for 6+ days and IGF-1 1.5-3x for 9-11 days in healthy adults. Well-tolerated at 30-60 µg/kg.
ModerateCJC-1295 preserves pulsatile GH secretion in humans
Ionescu & Bhatt (J. Clin. Endocrinol. Metab.): Demonstrates 7.5-fold increase in basal GH, 46% increase in mean GH, and 45% increase in IGF-1 while preserving natural pulsatile pattern.
ModerateLong-acting GHRH analogs increase pituitary GH mRNA
Animal study shows CJC-1295 increases total pituitary RNA and GH mRNA, suggesting proliferation of somatotroph cells for sustained GH production.
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EmergingAnalysis of growth hormone releasing hormone and its analogs in urine using nano liquid chromatography coupled with quadrupole/orbitrap mass spectrometry.
A 2026 study demonstrated the successful development and validation of a highly sensitive mass spectrometry method for detecting growth hormone-releasing hormone (GHRH) and its analogs, including sermorelin, tesamorelin, and CJC-1295, in urine. The method achieved limits of detection suitable for anti-doping screening.
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A 2024 study demonstrated the successful development and validation of a simplified chromatographic-mass spectrometric method for detecting prohibited peptides, including insulins, GHRHs, and IGFs, in doping control urine samples. The approach met World Anti-Doping Agency standards and was verified using authentic post-administration samples.
Preclinical§ Safety Profile
Often stacked with Ipamorelin; injection site reactions possible. Not FDA-approved.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.
RouteSubQ
Dose Range1000–1000 mcg
Frequency3x/week
TimingPre-bed or morning fasted
Cycle Length8–8 weeks
BAC Water2.5 ml / 10mg vial
CJC-1295 DAC version has 7-day half-life. Mod GRF 1-29 (no DAC) has ~30min half-life.
§ Pharmacokinetics
⏱️ Half-Life: 7d
Plasma concentration over time§ Regulatory
🇺🇸USA
Research Only🇨🇦Canada
Research Only🇬🇧UK
Unregulated🇪🇺EU
Unregulated🇦🇺Australia
Prescription OnlyLast updated: 2026-01 · Laws change frequently. Verify current status in your jurisdiction.
§ Expected Outcomes
Week 1
Improved sleep depth; occasional GH flush sensation; increased hunger in morning
Weeks 2–4
Elevated energy and faster post-workout recovery; mild water retention
Month 2–3
Measurable lean mass improvements; visible fat redistribution; IGF-1 elevation confirmed on bloodwork
Long-term
Sustained GH axis support; anti-aging body composition benefits; improved bone density over 6+ months
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Water retention Usually resolves after first 2-4 weeks | ~15% of users | mild |
Headache / GH flush | ~8% of users | mild |
Injection site reaction | ~5% of users | mild |
Temporary fatigue | ~5% of users | mild |
Where to Source CJC-1295 for Research
Finding verified, high-purity CJC-1295 requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified CJC-1295✓ Third-party tested·✓ US shipping·✓ COA on every batch
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§ About the Author
Dr. E. Vance
Editorial Director, PeptiDex
Dr. E. Vance is the Editorial Director at PeptiDex and leads the platform's editorial division, ensuring that every published research summary meets rigorous preclinical citation standards. With a Ph.D. in Molecular Pharmacology from Columbia Univers...
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⚠ Educational only · Not medical advice · Most peptides are research-only / not FDA-approved