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⚠️ Educational only · Not medical advice · Consult a doctor · Most peptides are research-only / not FDA-approved for human use

IGF-1 LR3

Also: Insulin-like Growth Factor 1 Long R3

💉Growth Factor

How It Works

IGF-1 analog with extended half-life for muscle cell hyperplasia (new cell creation, not just hypertrophy). Promotes nitrogen retention and protein synthesis.

Primary Benefits

1Muscle growth
2recovery
3hyperplasia

Key Studies

IGF-1 LR3 promotes muscle growth in animal models

IGF-1 LR3 demonstrates significantly enhanced potency over native IGF-1 due to reduced binding protein affinity and extended half-life, promoting dose-dependent muscle growth.

preclinical

IGF-1 signaling: muscle repair and regeneration review

Philippou & Barton (Growth Hormone & IGF Res.): Comprehensive review of IGF-1's role in muscle satellite cell activation, myoblast proliferation, and skeletal muscle regeneration.

preclinical

IGF-1 and cancer risk comprehensive epidemiological review

Bowers et al.: Meta-analysis of epidemiological studies examining positive correlation between circulating IGF-1 levels and prostate, breast, and colorectal cancer risk.

moderate strong

Safety Notes

Potent; use caution. Risk of hypoglycemia. Theoretical cancer promotion concern well-documented in literature. Research-only.

Dosing Protocol

⚠️ For educational purposes only. Not medical advice. Consult a healthcare professional before using any peptide.

RouteSubQ
Dose Range20-50 mcg
FrequencyDaily
TimingPost-workout
Cycle Length4-6 weeks
BAC Water1 ml / 1mg vial

Very low doses. Inject post-workout for localized muscle effects. Monitor blood sugar closely. Short cycles only.

Half-Life Visualization

⏱️ Half-Life: 20h

Plasma concentration over time
100%50%0%0t½ = 20h

Legal Status by Country

🇺🇸USA
Research Only
🇨🇦Canada
Research Only
🇬🇧UK
Unregulated
🇪🇺EU
Unregulated
🇦🇺Australia
Research Only

Last updated: 2026-01 · Laws change frequently. Verify current status in your jurisdiction.

Expected Timeline

Week 1

Enhanced nutrient partitioning; increased post-workout pumps

Weeks 2-4

Lean mass and recovery improvements; possible hypoglycemia if undereating

Month 2-3

Significant body composition changes; hyperplasia (new cell creation) possible

Long-term

Theoretical cancer promotion risk with chronic use; short cycles essential

Side Effects & Incidence

Side EffectIncidenceSeverity

Hypoglycemia

Especially if dosed without food nearby; have glucose on hand

~10% of usersmoderate

Joint pain

~8% of usersmild

Headache

~5% of usersmild

Fluid retention

~10% of usersmild

Incidence rates sourced from published clinical trial data where available; otherwise based on community research observations.

Found in 1 Stack

Muscle Growth Stack

Maximize lean muscle gain through GH optimization, growth factor signaling, and myostatin inhibition

CJC-1295IpamorelinSermorelinFollistatin-344IGF-1 LR3

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