COMPOUNDTB-500
ALIASThymosin Beta-4 Fragment
CLASSRegenerative Peptide
HALF-LIFE~4 hours
MW4963.4 Da
FDA STATUSNot approved
BEST PRICE$3.20/mg (Amino Club + PEPTIDEX)
LAST VERIFIEDMay 2026
TB-500
Last reviewed May 27, 2026
Also known as: Thymosin Beta-4 fragment, Tβ4
Quick Answer
TB-500 (Thymosin Beta-4 fragment) is the primary cell-migration and tissue-regeneration peptide I track — frequently stacked with BPC-157 for injury recovery protocols. I source from Amino Club using code PEPTIDEX: $31.99 per 10mg vial after the 20% discount ($3.20/mg). Multiple vendors carry it, but Amino Club's batch-specific COAs are the most rigorous I've verified.
Where to Source
Ranked by $/mg1Amino Club Best $/mg
$31.99
$39.99Save $8.00
10mg vial
$4.00/mg
99%+ purityCOA · Apr 2026
Use code for 20% off:
Shop Amino Club Compare all 3 vendors →
Rankings independent · Research use only
Upregulates actin for cell migration and wound healing. Reduces inflammation, encourages new blood vessel growth, and supports stem cell maturation for tissue repair.
Where to Buy TB-500
COA-verified vendors · Use code PEPTIDEX for up to 20% off
* Prices for research peptide acquisition. Not therapeutic products.
| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
Amino ClubEditor's Pick | 99%+ | $39.9910 mg | $31.99Save 20% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop |
| 99%+ | $44.995 mg | $38.24Save 15% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop | |
| 98%+ | $45.005 mg | $22.50Save 50% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop | |
| 99%+ | $164.9710 mg | $140.22Save 15% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop |
Amino ClubEditor's Pick
$39.99 · 10 mg$31.99−20%
Use code PEPTIDEX for 20% off at Amino Club.
* Research vendor — verify your regional regulations before purchase.
Shop at Amino Club$44.99 · 5 mg$38.24−15%
Use code PEPTIDEX for 15% off at Limitless Life.
* Research vendor — verify your regional regulations before purchase.
Shop at Limitless Life$45.00 · 5 mg$22.50−50%
Use code PEPTIDEX for 50% off at Ascension Peptides.
* Research vendor — verify your regional regulations before purchase.
Shop at Ascension Peptides$164.97 · 10 mg$140.22−15%
Use code PEPTIDEX for 15% off at Bio Longevity Labs.
* Research vendor — verify your regional regulations before purchase.
Shop at Bio Longevity Labs§ Mechanism of Action
Upregulates actin for cell migration and wound healing. Reduces inflammation, encourages new blood vessel growth, and supports stem cell maturation for tissue repair.
§ Primary Benefits
- 1Muscle/tissue repair
- 2flexibility
- 3injury recovery
§ Clinical Evidence
Thymosin Beta-4 wound healing and inflammation
Malinda et al. demonstrate Tβ4 promotes wound healing via enhanced reepithelialization, collagen deposition, angiogenesis, and keratinocyte migration in animal models.
PreclinicalThymosin β4 activates cardiac progenitor cells for myocardial repair
Smart et al. (Nature) show Tβ4 activates endogenous cardiac progenitor cells, initiating myocardial and vascular regeneration after systemic administration in mice.
PreclinicalThymosin β4 Phase I safety study in healthy volunteers
Phase I clinical trial demonstrates recombinant Tβ4 is well-tolerated at multiple IV doses in healthy volunteers, with no dose-limiting toxicities or serious adverse events.
ModerateThymosin β4 promotes dermal healing in diverse models
Tβ4 accelerates dermal healing in normal, diabetic, steroid-treated, and aged animal models. Phase 2 results show modest efficacy in venous stasis and pressure ulcers.
ModerateThymosin β4 reduces cardiac fibrosis and scar formation
Wei et al. show Tβ4 reduces scar formation post-myocardial infarction by inhibiting ROCK1 signaling, promoting neovascularization, and activating cardioprotective pathways.
PreclinicalTherapeutic peptides in gerontology: mechanisms and applications for healthy aging.
A study published in Frontiers in aging investigating the effects and mechanisms.
PreclinicalAdsorption effects of the doping relevant peptides Insulin Lispro, Synachten, TB-500 and GHRP 5.
A study published in Analytical biochemistry investigating the effects and mechanisms.
PreclinicalSynthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential.
A study published in Drug testing and analysis investigating the effects and mechanisms.
PreclinicalDoping control analysis of seven bioactive peptides in horse plasma by liquid chromatography-mass spectrometry.
A study published in Analytical and bioanalytical chemistry investigating the effects and mechanisms.
PreclinicalDetecting peptidic drugs, drug candidates and analogs in sports doping: current status and future directions.
A study published in Expert review of proteomics investigating the effects and mechanisms.
Preclinical§ Safety Profile
Research-only; well-tolerated in Phase I/II trials. Not FDA-approved for systemic use.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range2500–2500 mcg
Frequency2x/wk
TimingAny time
Cycle Length8–8 weeks
BAC Water2.5 ml / 5mg vial
Loading phase: 5mg 2x/week for 4 weeks. Maintenance: 2.5mg 2x/week.
§ Pharmacokinetics
⏱️ Half-Life: 2h
Plasma concentration over time§ Regulatory
🇺🇸USA
Research Only🇨🇦Canada
Research Only🇬🇧UK
Unregulated🇪🇺EU
Unregulated🇦🇺Australia
Prescription OnlyLast updated: 2026-01 · Laws change frequently. Verify current status in your jurisdiction.
§ Expected Outcomes
Week 1
Systemic anti-inflammatory effect; improved muscle pliability and reduced stiffness
Weeks 2–4
Improved range of motion; reduced recovery time after training
Month 2–3
Enhanced tissue repair; measurable improvement in chronic injury sites
Long-term
Improved recovery baseline; potential stem cell mobilization benefits
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Injection site reaction | ~8% of users | mild |
Transient fatigue | ~4% of users | mild |
Headache | ~3% of users | mild |
Where to Source TB-500 for Research
Finding verified, high-purity TB-500 requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified TB-500✓ Third-party tested·✓ US shipping·✓ COA on every batch
Disclosure: PeptiDex may earn a commission from purchases made through affiliate links. This does not affect our editorial independence or recommendations. We exclusively feature vendors that pass our strict quality verification protocols.
PEPTIDEX coupon for TB-500Save 20% on TB-500 at Amino Club & verified vendors →
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Reconstitution CalculatorCalculate reconstitution for TB-500 →
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TB-500 is the regenerative peptide I pair with BPC-157 in most tissue-repair research stacks — they work through complementary mechanisms. TB-500 promotes cell migration via actin polymerization while BPC-157 drives angiogenesis and nitric oxide release.
I verified Amino Club batch TB0001 at 99.924% purity via Biogenica Labs — MW at 4963.4 Da. At $31.99/10mg after the PEPTIDEX code, Amino Club has the best price-per-mg in my index for this compound. The COA PDF is linked below.
The equine research on thymosin beta-4 (the parent compound) is actually the most extensive dataset — TB-500 has been used in veterinary contexts for decades. The human research is more limited but the mechanistic rationale from the actin-sequestration data is solid.
📄 View COA: TB0001 (99.924% HPLC, 4963.4 Da)Full disclosure — PEPTIDEX is my affiliate code. I source TB-500 from Amino Club for the best pricing and from Limitless Life when I want their specific batch documentation.
Related Articles
Peptide Cycle Length: A Complete Research Guide for 2026
A comprehensive scientific guide to peptide cycle lengths. We explain receptor downregulation, angiogenic risks, and how to safely cycle BPC-157, TB-500, and secretagogues.
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Best Peptide Stack for Injury Recovery in 2026: A Research Guide
A deep dive into the best peptide stacks for injury recovery. We analyze the synergistic effects of BPC-157, TB-500, and growth hormone secretagogues for tissue repair.
Research News2026-04-30
Peptide Stacking in 2026: Why Combination Protocols Are Redefining Results
A deep dive into peptide stacking protocols — the Wolverine stack (BPC-157 & TB-500), growth hormone synergy (CJC-1295 & Ipamorelin), longevity and cognitive stacks, and how to combine compounds effectively.
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A comprehensive analysis of the 2026 FDA peptide reclassification — which 14 peptides are returning to Category 1, what it means for patients and providers, and how to navigate peptide therapy safely.
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