Overview
Cortagen is classified as a khavinson peptide peptide. Neuroregeneration, peripheral nerve repair, cardiac protection, anti-aging.
Synthetic tetrapeptide (Ala-Glu-Asp-Pro) Khavinson bioregulatory peptide with tissue-specific regulatory activity in cortical and peripheral nerve tissue. Penetrates cell nuclei, modulates gene expression profiles associated with neuroregeneration, and stimulates differentiation of neuronal progenitor cells. Also documented with cardioprotective effects via modulation of cardiac gene expression.
Also known as: Ala-Glu-Asp-Pro, AEDP
Category
Khavinson Peptide
Route
SubQ
FDA Status
Not Approved
How Does Cortagen Work?
Synthetic tetrapeptide (Ala-Glu-Asp-Pro) Khavinson bioregulatory peptide with tissue-specific regulatory activity in cortical and peripheral nerve tissue. Penetrates cell nuclei, modulates gene expression profiles associated with neuroregeneration, and stimulates differentiation of neuronal progenitor cells. Also documented with cardioprotective effects via modulation of cardiac gene expression.
At the molecular level, Cortagen operates through pathways characteristic of the Khavinson Peptide class, interacting with target receptors and downstream signaling cascades to produce its observed effects.
Published Research
The following studies are indexed from PubMed and peer-reviewed journals:
[1]Cortagen: cellular and molecular mechanisms of neuroprotection
Khavinson et al.: Cortagen demonstrates neuroprotective effects in a rat cortical neuron ischemia model by modulating gene expression and reducing apoptosis in damaged neuronal tissue.
Evidence: preclinical[2]Short peptide regulation of cardiac gene expression
Khavinson et al.: Cortagen modulates cardiac gene expression and reduces myocardial injury markers in rodent ischemia models, suggesting a cardioprotective role.
Evidence: preclinicalSafety Profile
⚠ PRECLINICAL RESEARCH ONLY. Based entirely on Khavinson group publications. No Western clinical trials. Not FDA-approved. Research only. Limited reproducibility data outside the originating research group.
| Side Effect | Incidence | Severity |
|---|---|---|
| Injection site reaction | Rare | mild |
Sourcing Cortagen for Research
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Full Research Profile
Cortagen — dosing, interactions, timelines & more
Comprehensive compound profile with sourcing information, stacking synergies, and outcome timelines.