Overview
Pinealon is classified as a khavinson peptide peptide. Neuroprotection, cognitive enhancement, antioxidant, circadian rhythm support.
Synthetic tripeptide (Glu-Asp-Arg) bioregulatory peptide developed by Khavinson's St. Petersburg Institute. Acts as a penetrating peptide that crosses the blood-brain barrier and enters neuronal cell nuclei. Modulates gene expression in brain tissue, upregulates antioxidant enzymes (catalase, superoxide dismutase), promotes neuroprotection, and supports the pineal gland's circadian regulation. Shown to reduce hypoxia-induced neuronal damage.
Also known as: EDR peptide, Glu-Asp-Arg
Category
Khavinson Peptide
Route
SubQ
FDA Status
Not Approved
How Does Pinealon Work?
Synthetic tripeptide (Glu-Asp-Arg) bioregulatory peptide developed by Khavinson's St. Petersburg Institute. Acts as a penetrating peptide that crosses the blood-brain barrier and enters neuronal cell nuclei. Modulates gene expression in brain tissue, upregulates antioxidant enzymes (catalase, superoxide dismutase), promotes neuroprotection, and supports the pineal gland's circadian regulation. Shown to reduce hypoxia-induced neuronal damage.
At the molecular level, Pinealon operates through pathways characteristic of the Khavinson Peptide class, interacting with target receptors and downstream signaling cascades to produce its observed effects.
Published Research
The following studies are indexed from PubMed and peer-reviewed journals:
[1]Pinealon increases resistance of neuronal cells to hypoxia
Khavinson et al.: Pinealon treatment increased resistance of human neuroblastoma cells to hypoxia, upregulating catalase and superoxide dismutase expression and reducing oxidative damage.
Evidence: preclinical[2]Peptide regulation of aging via epigenetic mechanisms
Khavinson et al.: Review documenting the epigenetic mechanisms by which short Khavinson peptides including Pinealon modulate histone acetylation and gene expression in brain tissue to slow aging.
Evidence: preclinicalSafety Profile
Based on Russian bioregulatory research. Limited Western RCT validation. Generally considered safe in published use. Not FDA-approved. Research only. Caution: Khavinson research base has limited independent Western reproducibility.
| Side Effect | Incidence | Severity |
|---|---|---|
| Injection site reaction | Rare | mild |
Sourcing Pinealon for Research
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Full Research Profile
Pinealon — dosing, interactions, timelines & more
Comprehensive compound profile with sourcing information, stacking synergies, and outcome timelines.