Overview
GHRP-2 is classified as a ghrp peptide. Strongest GH release of standard GHRPs, muscle growth, anti-aging, recovery.
Synthetic hexapeptide GH secretagogue acting on the GHSR1a receptor. GHRP-2 produces the most potent GH release among standard GHRPs (stronger than GHRP-6 or Ipamorelin) but with moderate increases in cortisol and prolactin. Approved in Japan as a diagnostic tool for GH deficiency (trade name: Pralmorelin/GHRP Kaken).
Also known as: Growth Hormone Releasing Peptide-2, Pralmorelin, KP-102
Category
GHRP
Half-Life
1.5h
Route
SubQ
FDA Status
Not Approved
How Does GHRP-2 Work?
Synthetic hexapeptide GH secretagogue acting on the GHSR1a receptor. GHRP-2 produces the most potent GH release among standard GHRPs (stronger than GHRP-6 or Ipamorelin) but with moderate increases in cortisol and prolactin. Approved in Japan as a diagnostic tool for GH deficiency (trade name: Pralmorelin/GHRP Kaken).
At the molecular level, GHRP-2 operates through pathways characteristic of the GHRP class, interacting with target receptors and downstream signaling cascades to produce its observed effects.
Published Research
The following studies are indexed from PubMed and peer-reviewed journals:
[1]GHRP-2 potent GH release in healthy adults
Arvat et al. (J. Clin. Endocrinol. Metab.): GHRP-2 produces the strongest GH response among tested GHRPs in healthy adults, with dose-dependent effects and moderate prolactin/cortisol elevation.
Evidence: moderate[2]GHRP-2 approved diagnostic agent for GH deficiency
Clinical validation of GHRP-2 (Pralmorelin) as a diagnostic GH provocative test in Japan, showing reliable, reproducible GH stimulation for diagnosing adult GH deficiency.
Evidence: strong[3]GHRP-2 effects on sleep and nocturnal GH secretion
Frieboes et al.: GHRP-2 enhances slow-wave sleep and amplifies nocturnal GH pulses in healthy young men, supporting pre-bed dosing protocols.
Evidence: moderate[4]GHRP-2 increases IGF-1 and lean mass in elderly
Bowers et al.: Chronic GHRP-2 administration in elderly subjects increases IGF-1, GH, and lean body mass while reducing fat mass.
Evidence: moderateSafety Profile
The most potent standard GHRP. Approved in Japan as a diagnostic tool (Pralmorelin). Raises cortisol and prolactin more than Ipamorelin but less than Hexarelin. Not FDA-approved for therapeutic use.
| Side Effect | Incidence | Severity |
|---|---|---|
| Moderate appetite increase | ~30% of users | mild |
| Cortisol elevation (transient) | ~20% of users | mild |
| Prolactin elevation (transient) | ~15% of users | mild |
| Water retention | ~12% of users | mild |
| Drowsiness / fatigue | ~8% of users | mild |
Sourcing GHRP-2 for Research
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Full Research Profile
GHRP-2 — dosing, interactions, timelines & more
Comprehensive compound profile with sourcing information, stacking synergies, and outcome timelines.