Overview
Ipamorelin is classified as a ghrp peptide. GH release, muscle growth, recovery without cortisol spike.
Selective GH secretagogue that mimics ghrelin at the GHS receptor. Does not significantly raise cortisol or prolactin, making it one of the most selective GH-releasing peptides.
Category
GHRP
Half-Life
2h
Route
SubQ
FDA Status
Not Approved
How Does Ipamorelin Work?
Selective GH secretagogue that mimics ghrelin at the GHS receptor. Does not significantly raise cortisol or prolactin, making it one of the most selective GH-releasing peptides.
At the molecular level, Ipamorelin operates through pathways characteristic of the GHRP class, interacting with target receptors and downstream signaling cascades to produce its observed effects.
Published Research
The following studies are indexed from PubMed and peer-reviewed journals:
[1]Ipamorelin selective GH release original characterization
Raun et al. (Eur. J. Endocrinol.): First characterization showing Ipamorelin releases GH potently and selectively without raising ACTH, cortisol, prolactin, FSH, LH, or TSH in swine.
Evidence: moderate[2]Ipamorelin PK/PD modeling in healthy human volunteers
Dose-escalation study in healthy humans demonstrates Ipamorelin induces single-episode GH release with peak at ~0.67 hours and terminal half-life of 2 hours.
Evidence: moderate[3]Ipamorelin and longitudinal bone growth in rats
Svensson et al. show Ipamorelin induces dose-dependent longitudinal bone growth and counters glucocorticoid-induced decreases in bone formation and muscle strength.
Evidence: preclinical[4]Ipamorelin accelerates postoperative GI recovery
Preclinical evidence demonstrates Ipamorelin alleviates delayed gastric emptying and post-surgical ileus, suggesting applications beyond hormone optimization.
Evidence: preclinicalSafety Profile
One of the safest GH peptides. Side effects may include transient headache, flushing. Not FDA-approved.
| Side Effect | Incidence | Severity |
|---|---|---|
| Temporary hunger | ~12% of users | mild |
| Headache | ~5% of users | mild |
| Water retention | ~8% of users | mild |
| Flushing / warmth | ~4% of users | mild |
Sourcing Ipamorelin for Research
If you're looking to source Ipamorelin for laboratory research, our vendor directory compares pricing, purity testing, and COA verification from independently vetted suppliers.
Disclosure: PeptiDex may earn a commission from affiliate links. This does not affect our recommendations.
Full Research Profile
Ipamorelin — dosing, interactions, timelines & more
Comprehensive compound profile with sourcing information, stacking synergies, and outcome timelines.