Overview
MOTS-c is classified as a mitochondrial peptide peptide. Energy, metabolism, fat loss, longevity.
Regulates mitochondrial function and AMPK. Enhances glucose uptake and fatty acid oxidation, improves insulin sensitivity, and protects against age-related metabolic decline.
Also known as: Mitochondrial ORF of 12S rRNA Type-c
Category
Mitochondrial Peptide
Half-Life
4h
Route
SubQ
FDA Status
Not Approved
How Does MOTS-c Work?
Regulates mitochondrial function and AMPK. Enhances glucose uptake and fatty acid oxidation, improves insulin sensitivity, and protects against age-related metabolic decline.
At the molecular level, MOTS-c operates through pathways characteristic of the Mitochondrial Peptide class, interacting with target receptors and downstream signaling cascades to produce its observed effects.
Published Research
The following studies are indexed from PubMed and peer-reviewed journals:
[1]MOTS-c regulates metabolic homeostasis (Cell Metabolism)
Lee et al. (Cell Metabolism): Discovery paper showing MOTS-c is a mitochondrial-derived peptide that regulates insulin sensitivity and metabolic homeostasis via AMPK activation.
Evidence: emerging[2]MOTS-c prevents age-related insulin resistance in mice
Lee et al.: MOTS-c treatment prevents both age-dependent and high-fat-diet-induced insulin resistance and diet-induced obesity in mouse models.
Evidence: preclinical[3]MOTS-c improves skeletal muscle glucose metabolism
Study demonstrating MOTS-c specifically targets skeletal muscle glucose metabolism, providing molecular basis for metabolic benefits and exercise-mimetic properties.
Evidence: preclinical[4]Circulating MOTS-c levels decline with age and obesity
Human observational study linking decreased circulating MOTS-c levels with aging, obesity, and type 2 diabetes suggesting therapeutic rationale for supplementation.
Evidence: emergingSafety Profile
Promising but limited human data. As an endogenous peptide, theoretical biocompatibility favorable.
| Side Effect | Incidence | Severity |
|---|---|---|
| Injection site reaction | ~5% of users | mild |
| Generally well-tolerated | Very limited human data | mild |
Sourcing MOTS-c for Research
If you're looking to source MOTS-c for laboratory research, our vendor directory compares pricing, purity testing, and COA verification from independently vetted suppliers.
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Full Research Profile
MOTS-c — dosing, interactions, timelines & more
Comprehensive compound profile with sourcing information, stacking synergies, and outcome timelines.