Kisspeptin-10
Last reviewed May 27, 2026
Also known as: KP-10, Metastin 45-54, KISS1
Quick Answer
Kisspeptin-10 is a reproductive peptide research compound (not FDA-approved for human use) studied for lh/fsh stimulation. Kisspeptin-10 is a naturally occurring reproductive neuropeptide studied for stimulating testosterone production in men and supporting ovulation in women by activating the HPG hormonal axis. Research dose: 100–100 mcg 3x/wk. Half-life: 30 minutes. Available from COA-verified vendors with code PEPTIDEX for up to 20% off.
Where to Source
Ranked by $/mg1Bio Longevity Labs Best $/mg
$55.22
$64.97Save $9.75
10mg vial
$6.50/mg
99%+ purityTested May 2026
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Rankings independent · Research use only
Endogenous neuropeptide that is the master upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin-10 binds to the GPR54 (KISS1R) receptor on GnRH neurons, triggering pulsatile
Where to Buy Kisspeptin-10
COA-verified vendors · Use code PEPTIDEX for up to 20% off
* Prices for research peptide acquisition. Not therapeutic products.
| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
Bio Longevity LabsTriple-Tested | 99%+ | $64.9710 mg | $55.22Save 15% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop |
Bio Longevity LabsTriple-Tested
$64.97 · 10 mg$55.22−15%
Use code PEPTIDEX for 15% off at Bio Longevity Labs.
* Research vendor — verify your regional regulations before purchase.
Shop at Bio Longevity Labs§ Mechanism of Action
Endogenous neuropeptide that is the master upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin-10 binds to the GPR54 (KISS1R) receptor on GnRH neurons, triggering pulsatile GnRH release which stimulates LH and FSH secretion from the pituitary. This cascade drives testosterone production in males and ovulation in females. Unique advantage: activates the reproductive axis at its highest control point without bypassing natural feedback loops.
§ Primary Benefits
- 1LH/FSH stimulation
- 2testosterone support
- 3fertility enhancement
- 4HPG axis activation
§ Clinical Evidence
Kisspeptin potently stimulates LH and testosterone in healthy men
Dhillo et al. (J. Clin. Endocrinol. Metab.): IV Kisspeptin-10 (1mcg/kg) potently stimulates LH pulse frequency and testosterone secretion in healthy men, establishing its role as a reproductive axis activator.
ModerateKisspeptin restores LH pulsatility in hypogonadal men
George et al.: Kisspeptin-10 infusion restores LH pulsatility and increases testosterone in men with type 2 diabetes-associated hypogonadism, demonstrating therapeutic potential.
ModerateKisspeptin as alternative oocyte maturation trigger in IVF
Abbara et al. (J. Clin. Invest.): Kisspeptin-54 triggers oocyte maturation in women undergoing IVF with significantly lower risk of ovarian hyperstimulation syndrome (OHSS) vs. hCG trigger.
StrongKisspeptin stimulates reproductive hormones in women
Jayasena et al.: Kisspeptin-10 administration increases LH secretion in women, with response magnitude dependent on menstrual cycle phase (strongest in preovulatory phase).
ModerateKisspeptin tachyphylaxis with continuous administration
Ramaswamy et al.: Continuous Kisspeptin-10 infusion leads to desensitization of the HPG axis within 24-48 hours, indicating pulsatile dosing protocols are necessary for sustained efficacy.
PreclinicalKnockout of PI4-Kinase A in GnRH Neurons Causes their Prepubertal Death.
In a 2026 study on mice, researchers demonstrated that phosphatidylinositol 4-kinase alpha is essential for the postnatal survival of GnRH neurons, though not for their embryonic development. The study found that knocking out this enzyme caused prepubertal neuron death, resulting in infertility in both sexes.
PreclinicalDiagnostic Criteria and Genetic Basis of Polycystic Ovary Syndrome: A Narrative Review.
Polymorphisms in genes regulating insulin metabolism, steroidogenesis, and the hypothalamic-pituitary-ovarian axis were found to drive the clinical variability of Polycystic Ovary Syndrome. A 2026 review investigated these genetic markers to highlight their role in the disorder's pathophysiology.
EmergingSpatial transcriptional mapping reveals the molecular characteristics of juxtaglomerular cell tumors.
High KISS1 expression and the PPARG, NOTCH, and PDGFB pathways were identified as key regulators of juxtaglomerular cell tumor development and renin secretion in a 2026 spatial transcriptomic analysis. The study demonstrated that REN expression positively correlates with KISS1 across multiple tumor types.
EmergingPhotoperiodic modulation of puberty through melatonin-kisspeptin-GnRH signalling in female Wistar rats.
A 2026 study in female Wistar rats demonstrated that photoperiod-dependent melatonin signaling and estradiol synergistically modulate hypothalamic gene networks crucial for pubertal regulation. Researchers found that long-day photoperiods advanced puberty, while melatonin suppressed Kiss1 and GnRH expression in vitro.
PreclinicalExpressions of Kisspeptin System and Ki-67 in the Reproductive Tissues of Cyclic Bitches.
A 2026 study in female dogs demonstrated that kisspeptin (KISS1) and Ki-67 expression significantly increased in the endometrium during estrus. These findings suggest that local kisspeptin signaling plays a coordinated role in endometrial proliferation and tissue remodeling during the reproductive cycle.
Preclinical§ Safety Profile
Endogenous human neuropeptide with growing clinical trial data. Tachyphylaxis (desensitization) occurs with continuous dosing; pulsatile/intermittent protocols required. Being investigated as a safer IVF trigger (vs. hCG). Not FDA-approved for therapeutic use. Research-only.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range100–100 mcg
Frequency3x/wk
TimingMorning or split AM/PM
Cycle Length8–8 weeks
BAC Water2.5 ml / 5mg vial
Pulsatile dosing critical: continuous administration causes desensitization within 24-48 hours. Clinical studies use 1mcg/kg IV or 100-400mcg SubQ. Cycle 5 days on / 2 days off to prevent tachyphylaxis. Monitor LH, FSH, testosterone/estradiol on bloodwork.
§ Pharmacokinetics
⏱️ Half-Life: 30min
Plasma concentration over time§ Expected Outcomes
Week 1
Acute LH surge within hours; increase in morning testosterone levels; improved libido in hypogonadal individuals
Weeks 2–4
Sustained testosterone elevation with pulsatile dosing; improved energy and mood; fertility markers improving
Month 2–3
Stable HPG axis activation; measurable testosterone/LH improvement on bloodwork; improved reproductive parameters
Long-term
Must maintain pulsatile dosing to avoid desensitization; promising IVF trigger data; long-term reproductive axis support
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Injection site reaction | ~8% of users | mild |
Mild headache | ~5% of users | mild |
Flushing / warmth | ~5% of users | mild |
Tachyphylaxis (with continuous dosing) Not a side effect per se but a dosing limitation; pulsatile protocols prevent this | Variable | moderate |
Where to Source Kisspeptin-10 for Research
Finding verified, high-purity Kisspeptin-10 requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
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§ Community Stacks
Hormonal Optimization Stack (Male)
Naturally stimulate the HPG axis to boost testosterone without shutting down natural production
Cite This Page
⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
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