What Is Tesofensine?
Tesofensine (NS2330) is classified as a small molecule peptide. Triple monoamine reuptake inhibitor (inhibits reuptake of serotonin, noradrenaline, and dopamine). Originates as an Alzheimer's/Parkinson's drug but abandoned due to massive weight loss profiles.
It is extensively evaluated in laboratory and clinical settings for its potential to drive extreme fat loss and appetite suppression without glp-1 side effects. Researchers target Tesofensine for its ability to interact with specific cellular and molecular pathways, making it a compound of significant interest across multiple therapeutic domains.
Research-only. Potent CNS stimulant. Can cause insomnia, elevated heart rate, and dry mouth. Half-life is extremely long, leading to accumulation in the system.
How Does Tesofensine Work?
Triple monoamine reuptake inhibitor (inhibits reuptake of serotonin, noradrenaline, and dopamine). Originates as an Alzheimer's/Parkinson's drug but abandoned due to massive weight loss profiles.
At the molecular level, Tesofensine operates through pathways characteristic of the Small Molecule class. By interacting with target receptors and downstream signaling cascades, the compound initiates biological responses associated with extreme fat loss and appetite suppression without glp-1 side effects.
Expected Research Timeline
Months 2–3
10%+ body weight loss
What Does the Research Say?
The following are key findings from peer-reviewed studies on Tesofensine, indexed on PubMed and equivalent databases:
Safety & Side Effects
Research-only. Potent CNS stimulant. Can cause insomnia, elevated heart rate, and dry mouth. Half-life is extremely long, leading to accumulation in the system.
| Side Effect | Incidence | Severity |
|---|---|---|
| Insomnia | ~15% of users | moderate |
| Dry Mouth | ~20% of users | mild |
| Elevated Heart Rate | ~12% of users | moderate |
FDA Status: Not Approved for Human Therapeutic Use
Tesofensine is not currently FDA-approved for human use. It is available for research purposes only. Always consult a licensed healthcare provider.
How Is Tesofensine Used?
Route
Oral
Dose Range
250–500 mcg
Frequency
Daily
Cycle
12–24 wk
Timing: Early Morning
Notes: Do not exceed 0.5mg/day due to heart rate spikes. Taken via capsule, not injected.
All dosing information reflects parameters reported in published research literature and is not intended as clinical guidance. Usage of any peptide should be supervised by a qualified healthcare professional.
Where to Source Tesofensine for Research
Purchasing ultra-high purity, laboratory-grade peptides is critical for verifiable research. We only recommend vendors providing independent, third-party HPLC Certificates of Analysis (COA).
Disclosure: PeptiDex may earn a commission from purchases. This does not affect our recommendations. We exclusively feature vendors that pass our strict quality verification protocols.
Frequently Asked Questions
What is Tesofensine?
Tesofensine is a small molecule peptide. Triple monoamine reuptake inhibitor (inhibits reuptake of serotonin, noradrenaline, and dopamine). Originates as an Alzheimer's/Parkinson's drug but abandoned due to massive weight loss profiles.
What are the primary research benefits of Tesofensine?
Published research identifies primary mechanisms targeting: Extreme fat loss and appetite suppression without GLP-1 side effects. These findings come from 1+ peer-reviewed studies indexed in our database.
What is the half-life of Tesofensine?
In published pharmacokinetic data, Tesofensine demonstrates a half-life of approximately 216 hours.
Is Tesofensine FDA approved?
Tesofensine is not currently FDA-approved for human therapeutic use. It is classified as a research compound and is studied under investigational protocols. Always consult a healthcare provider.
What are common side effects of Tesofensine?
Reported side effects in published literature include Insomnia (~15% of users), Dry Mouth (~20% of users), Elevated Heart Rate (~12% of users). Most are classified as moderate in severity.
How is Tesofensine administered?
In research settings, Tesofensine is typically administered via Oral. Do not exceed 0.5mg/day due to heart rate spikes. Taken via capsule, not injected.
Sources
- Tesofensine induces profound weight loss. View on PubMed