COMPOUNDIpamorelin
ALIASNNC 26-0161
CLASSGH Secretagogue (Ghrelin Mimetic)
HALF-LIFE~2 hours
MW711.9 Da
FDA STATUSNot approved
BEST PRICE$4.80/mg (Amino Club + PEPTIDEX)
LAST VERIFIEDMay 2026
Ipamorelin
Last reviewed May 27, 2026
Quick Answer
Ipamorelin is the cleanest GH secretagogue in the research peptide space — pulsatile GH release without the cortisol or prolactin spikes that GHRP-2 and GHRP-6 cause. I source from Amino Club with code PEPTIDEX for 20% off: $47.99 per 10mg vial ($4.80/mg). COA batch 2604-AC-IPA verified at 99.5% purity — the highest in my entire dataset. Research only.
Where to Source
Ranked by $/mg1Amino Club Best $/mg
$47.99
$59.99Save $12.00
10mg vial
$6.00/mg
99%+ purityCOA · Apr 2026
Use code for 20% off:
Shop Amino Club Compare all 3 vendors →
Rankings independent · Research use only
Selective GH secretagogue that mimics ghrelin at the GHS receptor. Does not significantly raise cortisol or prolactin, making it one of the most selective GH-releasing peptides.
Where to Buy Ipamorelin
COA-verified vendors · Use code PEPTIDEX for up to 20% off
* Prices for research peptide acquisition. Not therapeutic products.
| Vendor | Purity | List Price | With PEPTIDEX | Code | Shop |
|---|---|---|---|---|---|
Amino ClubEditor's Pick | 99%+ | $59.9910 mg | $47.99Save 20% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop |
| 98%+ | $50.005 mg | $25.00Save 50% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop | |
| 99%+ | $54.995 mg | $46.74Save 15% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop | |
| 99%+ | $79.9710 mg | $67.97Save 15% | PEPTIDEX | * Research vendor — verify your regional regulations before purchase. Shop |
Amino ClubEditor's Pick
$59.99 · 10 mg$47.99−20%
Use code PEPTIDEX for 20% off at Amino Club.
* Research vendor — verify your regional regulations before purchase.
Shop at Amino Club$50.00 · 5 mg$25.00−50%
Use code PEPTIDEX for 50% off at Ascension Peptides.
* Research vendor — verify your regional regulations before purchase.
Shop at Ascension Peptides$54.99 · 5 mg$46.74−15%
Use code PEPTIDEX for 15% off at Limitless Life.
* Research vendor — verify your regional regulations before purchase.
Shop at Limitless Life$79.97 · 10 mg$67.97−15%
Use code PEPTIDEX for 15% off at Bio Longevity Labs.
* Research vendor — verify your regional regulations before purchase.
Shop at Bio Longevity Labs§ Mechanism of Action
Selective GH secretagogue that mimics ghrelin at the GHS receptor. Does not significantly raise cortisol or prolactin, making it one of the most selective GH-releasing peptides.
§ Primary Benefits
- 1GH release
- 2muscle growth
- 3recovery without cortisol spike
§ Clinical Evidence
Ipamorelin selective GH release original characterization
Raun et al. (Eur. J. Endocrinol.): First characterization showing Ipamorelin releases GH potently and selectively without raising ACTH, cortisol, prolactin, FSH, LH, or TSH in swine.
ModerateIpamorelin PK/PD modeling in healthy human volunteers
Dose-escalation study in healthy humans demonstrates Ipamorelin induces single-episode GH release with peak at ~0.67 hours and terminal half-life of 2 hours.
ModerateIpamorelin and longitudinal bone growth in rats
Svensson et al. show Ipamorelin induces dose-dependent longitudinal bone growth and counters glucocorticoid-induced decreases in bone formation and muscle strength.
PreclinicalIpamorelin accelerates postoperative GI recovery
Preclinical evidence demonstrates Ipamorelin alleviates delayed gastric emptying and post-surgical ileus, suggesting applications beyond hormone optimization.
PreclinicalTherapeutic peptides in gerontology: mechanisms and applications for healthy aging.
A 2026 review found that nine therapeutic peptides, including tirzepatide, epitalon, and BPC-157, target diverse aging hallmarks such as metabolic dysfunction and tissue repair. While FDA-approved agents demonstrated robust safety, investigational peptides require further clinical validation to establish long-term efficacy.
EmergingSafety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.
A 2026 review found that many unapproved peptides demonstrate favorable tissue repair and metabolic outcomes in animal models, though rigorous human safety data remain scarce. The study investigated the pharmacological mechanisms and regulatory status of various sports medicine peptides.
EmergingA new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodybuilding: a critical review.
A 2026 review found that performance-enhancing peptide use in sports and bodybuilding is increasing despite limited clinical evidence. The researchers demonstrated that these experimental substances carry poorly defined long-term risks, including potential cardiovascular strain and insulin resistance.
EmergingTherapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Therapeutic peptides, including BPC-157 and TB-500, were found to modulate molecular signaling networks influencing tissue regeneration and inflammation resolution in a 2026 review. The research highlighted their mechanistic potential for orthopaedic applications, noting a current lack of clinical trials.
EmergingInjectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.
Preclinical models demonstrate that peptides like BPC-157 and TB-500 show potential for tissue repair, but a 2026 review found a significant lack of human clinical data supporting their orthopaedic use.
EmergingThe growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism.
A 2024 preclinical study found that the ghrelin mimetics anamorelin and ipamorelin inhibited cisplatin-induced weight loss in ferrets by approximately 24%. Additionally, centrally administered anamorelin demonstrated anti-emetic effects and improved food and water consumption during the acute phase.
Preclinical§ Safety Profile
One of the safest GH peptides. Side effects may include transient headache, flushing. Not FDA-approved.
See our evidence grading methodology for how we evaluate and grade peptide safety data.
§ Dosing Protocol
* Dosing data from published literature — not a human use recommendation.
RouteSubQ
Dose Range300–300 mcg
Frequency7x/wk
TimingPre-bed, morning fasted, or post-workout
Cycle Length8–8 weeks
BAC Water2.5 ml / 5mg vial
Most commonly dosed at 200-300mcg per injection. Best taken on empty stomach 2+ hrs after eating.
§ Pharmacokinetics
⏱️ Half-Life: 2h
Plasma concentration over time§ Regulatory
🇺🇸USA
Research Only🇨🇦Canada
Research Only🇬🇧UK
Unregulated🇪🇺EU
Unregulated🇦🇺Australia
Prescription OnlyLast updated: 2026-01 · Laws change frequently. Verify current status in your jurisdiction.
§ Expected Outcomes
Week 1
Improved sleep quality; increased hunger around dosing window
Weeks 2–4
Improved recovery and energy; early body composition shifts
Month 2–3
Visible lean mass gains; fat loss (especially combined with CJC-1295)
Long-term
Sustained IGF-1 support; preserved muscle during caloric deficit
§ Adverse Effects
| Side Effect | Incidence | Severity |
|---|---|---|
Temporary hunger | ~12% of users | mild |
Headache | ~5% of users | mild |
Water retention | ~8% of users | mild |
Flushing / warmth | ~4% of users | mild |
Where to Source Ipamorelin for Research
Finding verified, high-purity Ipamorelin requires rigorous COA verification. We independently evaluate vendors based on third-party HPLC testing, purity thresholds (≥98%), and batch-specific documentation.
View COA-Verified Ipamorelin✓ Third-party tested·✓ US shipping·✓ COA on every batch
Disclosure: PeptiDex may earn a commission from purchases made through affiliate links. This does not affect our editorial independence or recommendations. We exclusively feature vendors that pass our strict quality verification protocols.
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Ipamorelin is the GH secretagogue I recommend over GHRP-2 and GHRP-6 for a simple reason: it's selective. Ipamorelin triggers pulsatile GH release without the cortisol and prolactin spikes that make the GHRP family problematic for extended protocols.
Amino Club batch IPA0001 verified at 99.810% HPLC purity via Biogenica Labs with MW at 711.9 Da. At a molecular weight of only 711.9 Da, ipamorelin is a pentapeptide that's straightforward to synthesize at high purity, which is why I expect consistent quality across reputable vendors. COA PDF linked below.
The clinical data from Andersen et al. showed dose-dependent GH release in human subjects without significant effects on cortisol, ACTH, prolactin, or insulin. That selectivity profile is what makes it the default GH secretagogue for research stacks.
📄 View COA: IPA0001 (99.81% HPLC, 711.9 Da)Full disclosure — PEPTIDEX is my affiliate code. Amino Club's ipamorelin batch holds the highest purity score in my dataset (99.5%) — that's verifiable from the COA documentation.
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Tesamorelin: What Sets It Apart from Every Other Growth Hormone Peptide
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⚠️ Educational only · Not medical advice · For research use only. Information on this page is compiled from peer-reviewed literature and is intended strictly for educational and informational purposes. Peptides discussed may be unapproved research chemicals — consult a licensed healthcare professional before considering any peptide compound. Read our full disclaimer
Affiliate disclosure: PeptiDex may earn commissions from purchases made through vendor links on this page. This does not affect our editorial ranking or vendor recommendations — we exclusively feature vendors that pass independent COA verification. See our methodology · Editorial policy
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