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Last reviewed: May 27, 2026 · PeptiDex Editorial Team
© 2026 PeptiDex. All rights reserved.PrivacyTermsDisclosures
Home/Tools/Evidence Map
Interactive Research Tool

Peptide Evidence Map

51 research peptides ranked by scientific evidence — from FDA-approved compounds to emerging research. Filter by goal, compare evidence tiers, and explore clinical data.

Last updated: April 2026•668 referenced studies•5 FDA-approved

Filter by Research Goal

Showing 51 of 51 peptides

FDA Approved

5 compounds

PT-141

Melanocortin Agonist

Sexual arousal, libido

FDA Approved19 studies

Semaglutide

GLP-1 Agonist

Fat loss, appetite control, cardiovascular benefits

FDA Approved20 studies

Tesamorelin

GHRH Analog

Visceral fat reduction, body recomposition

FDA Approved20 studies

Tirzepatide

Dual Agonist (GLP-1/GIP)

Weight loss, body recomposition, glycemic control

FDA Approved20 studies

Gonadorelin

GnRH Analog

LH/FSH stimulation, testosterone preservation, HPG axis support during TRT, fertility support

FDA Approved2 studies

Strong Clinical Evidence

14 compounds

Cagrilintide

Metabolic

Weight loss, appetite reduction, glycemic control

Strong Clinical Evidence20 studies

DSIP

Sleep Peptide

Improved sleep quality, stress reduction

Strong Clinical Evidence20 studies

Epitalon

Telomerase Activator

Anti-aging, longevity, sleep

Strong Clinical Evidence30 studies

GHRP-2

GHRP

Strongest GH release of standard GHRPs, muscle growth, anti-aging, recovery

Strong Clinical Evidence20 studies

Glutathione

Antioxidant

Detoxification, antioxidant defense, immune support, skin brightening

Strong Clinical Evidence20 studies

Kisspeptin-10

Reproductive Peptide

LH/FSH stimulation, testosterone support, fertility enhancement, HPG axis activation

Strong Clinical Evidence20 studies

KPV

Anti-Inflammatory

Gut/injury healing, inflammation reduction

Strong Clinical Evidence19 studies

MK-677

GH Secretagogue (Oral)

Sustained GH/IGF-1 elevation, muscle growth, improved sleep, bone density, oral dosing convenience

Strong Clinical Evidence20 studies

NAD+

Longevity

Cellular energy, DNA repair, longevity

Strong Clinical Evidence20 studies

Retatrutide

Triple Agonist (GLP-1/GIP/Glucagon)

Superior body recomposition, massive fat loss, metabolic health

Strong Clinical Evidence20 studies

Sermorelin

GHRH Analog

Muscle growth, recovery, sleep, anti-aging

Strong Clinical Evidence20 studies

Thymosin Alpha-1

Immune Peptide

Immune support, antiviral, recovery

Strong Clinical Evidence20 studies

Tesofensine

Small Molecule

Extreme fat loss and appetite suppression without GLP-1 side effects

Strong Clinical Evidence20 studies

Larazotide

Zonulin Antagonist

Gut barrier repair, tight junction integrity, celiac disease symptom reduction, leaky gut

Strong Clinical Evidence2 studies

Moderate / Preclinical Evidence

31 compounds

AOD-9604

GH Fragment

Fat loss without GH side effects

Moderate / Preclinical Evidence18 studies

BPC-157

Body Protective Compound

Injury recovery, gut healing, tissue repair, reduced inflammation

Moderate / Preclinical Evidence20 studies

CJC-1295

GHRH Analog

Muscle growth, fat loss, recovery

Moderate / Preclinical Evidence20 studies

Follistatin-344

Myostatin Inhibitor

Muscle hypertrophy, strength

Moderate / Preclinical Evidence9 studies

GHK-Cu

Copper Peptide

Skin repair, anti-aging, wound healing

Moderate / Preclinical Evidence20 studies

GHRP-6

GHRP

Potent GH release, appetite stimulation, muscle growth, recovery, gastric motility

Moderate / Preclinical Evidence20 studies

Hexarelin

GHRP

Most potent GH release of any GHRP, cardioprotection, muscle growth, recovery

Moderate / Preclinical Evidence4 studies

IGF-1 LR3

Growth Factor

Muscle growth, recovery, hyperplasia

Moderate / Preclinical Evidence20 studies

Ipamorelin

GHRP

GH release, muscle growth, recovery without cortisol spike

Moderate / Preclinical Evidence20 studies

LL-37

Antimicrobial Peptide

Broad-spectrum antimicrobial, anti-biofilm, wound healing, immune modulation, anti-inflammatory

Moderate / Preclinical Evidence20 studies

Melanotan II

Melanocortin Agonist

Tanning, libido enhancement

Moderate / Preclinical Evidence20 studies

MOTS-c

Mitochondrial Peptide

Energy, metabolism, fat loss, longevity

Moderate / Preclinical Evidence20 studies

Selank

Anxiolytic Peptide

Anxiety reduction, mental clarity, mood

Moderate / Preclinical Evidence20 studies

Semax

Cognitive Peptide

Mental clarity, focus, neuroprotection

Moderate / Preclinical Evidence20 studies

SS-31

Mitochondrial Peptide

Energy, recovery, neuroprotection

Moderate / Preclinical Evidence20 studies

TB-500

Thymosin Beta-4 Fragment

Muscle/tissue repair, flexibility, injury recovery

Moderate / Preclinical Evidence15 studies

Argireline

Cosmetic Peptide

Topical wrinkle reduction, SNAP-25 inhibition, muscle relaxation (neurocosmetic)

Moderate / Preclinical Evidence1 studies

5-Amino-1MQ

NNMT Inhibitor

Fat loss, NAD+ preservation, metabolic optimization, muscle protection

Moderate / Preclinical Evidence2 studies

ARA-290

EPO Receptor Agonist

Neuropathic pain relief, small fiber neuropathy, anti-inflammation, tissue protection

Moderate / Preclinical Evidence3 studies

VIP

Neuropeptide

Systemic anti-inflammation, CIRS/mold illness treatment, pulmonary vasodilation, immune modulation

Moderate / Preclinical Evidence2 studies

Oxytocin

Neuropeptide

Social bonding, anxiety reduction, gut motility, anti-inflammation, libido, trust and empathy

Moderate / Preclinical Evidence2 studies

Humanin

Mitochondrial Peptide

Neuroprotection, anti-apoptosis, insulin sensitization, longevity, Alzheimer's protection

Moderate / Preclinical Evidence3 studies

PE-22-28

Nootropic Peptide

Antidepressant, neuroplasticity, TREK-1 channel blockade, fast-acting mood elevation

Moderate / Preclinical Evidence2 studies

Pinealon

Khavinson Peptide

Neuroprotection, cognitive enhancement, antioxidant, circadian rhythm support

Moderate / Preclinical Evidence2 studies

Cortagen

Khavinson Peptide

Neuroregeneration, peripheral nerve repair, cardiac protection, anti-aging

Moderate / Preclinical Evidence2 studies

Dihexa

Neurotropic Peptide

Synaptogenesis, memory enhancement, cognitive repair, angiotensin IV activity

Moderate / Preclinical Evidence2 studies

FOXO4-DRI

Senolytic Peptide

Senescent cell elimination (senolytics), longevity, tissue rejuvenation, SASP reduction

Moderate / Preclinical Evidence1 studies

Klotho

Anti-Aging Protein

Cognitive aging reversal, kidney protection, cardiovascular protection, longevity, FGF23 regulation

Moderate / Preclinical Evidence2 studies

OS-01

Cosmetic Peptide

Skin cellular age reversal, senescent skin cell clearance, photoaging repair, epidermal renewal

Moderate / Preclinical Evidence1 studies

Synapsin

Nootropic Peptide

Cognitive enhancement, neuroprotection, mitochondrial function, synaptic plasticity

Moderate / Preclinical Evidence1 studies

FGL Loop

Neurotropic Peptide

Synaptogenesis, memory enhancement, NCAM-mediated neuroprotection

Moderate / Preclinical Evidence2 studies

Emerging / Limited Evidence

1 compound

Thymalin

Thymic Peptide

Immune restoration, longevity, thymic function support, T-cell maturation

Emerging / Limited Evidence2 studies

Methodology: How Evidence Tiers Are Assigned

FDA Approved

Peptides that have received U.S. FDA approval for at least one clinical indication, confirmed by the FDA Orange Book or drug label database.

Strong Clinical

Peptides with published Phase 2 or Phase 3 randomized controlled trials in humans, indexed on PubMed with statistically significant efficacy endpoints.

Moderate / Preclinical

Peptides with robust animal model data, in-vitro mechanistic evidence, or Phase 1 / early-phase human safety studies in peer-reviewed journals.

Emerging / Limited

Peptides with limited published research, preliminary mechanistic data, or where evidence is primarily anecdotal or based on case reports.

Evidence tiers are determined by the highest-quality study available for each peptide. Our editorial team reviews each classification monthly. Last updated: April 2026.

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This evidence map is for educational and research purposes only. It does not constitute medical advice. Evidence tiers reflect published peer-reviewed literature as of April 2026. PeptiDex may earn a commission from affiliate links. This does not affect our editorial independence.